N-[2-(1-benzenesulfonyl-3-bromo-1H-indole-2-carbonyl)-4-bromo-5-methoxy-phenyl]-acetamide

Base Information

• Chemical Name: N-[2-(1-benzenesulfonyl-3-bromo-1H-indole-2-carbonyl)-4-bromo-5-methoxy-phenyl]-acetamide
• CAS No.: 619297-32-4
• Molecular Formula: C₂₄H₁₈Br₂N₂O₅S
• Molecular Weight: 606.291
• Mol file: 619297-32-4.mol

Synonyms:N-[2-(1-benzenesulfonyl-3-bromo-1H-indole-2-carbonyl)-4-bromo-5-methoxy-phenyl]-acetamide

Chemical Property of N-[2-(1-benzenesulfonyl-3-bromo-1H-indole-2-carbonyl)-4-bromo-5-methoxy-phenyl]-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(1-benzenesulfonyl-3-bromo-1H-indole-2-carbonyl)-4-bromo-5-methoxy-phenyl]-acetamide

There total 4 articles about N-[2-(1-benzenesulfonyl-3-bromo-1H-indole-2-carbonyl)-4-bromo-5-methoxy-phenyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

N-{4-bromo-2-[(3-bromo-1-phenylsulfonyl-1H-indol-2-yl)methyl]-5-methoxyphenyl}acetamide (565227-62-5) → N-[2-(1-benzenesulfonyl-3-bromo-1H-indole-2-carbonyl)-4-bromo-5-methoxy-phenyl]-acetamide (619297-32-4)

Guidance literature:

With dipyridine chromium trioxide; In pyridine; at 50 - 60 ℃; for 48h;

DOI:10.1081/SCC-120021513

Reference yield:

3-bromo-2-(bromomethyl)-1-(phenylsulfonyl)-1H-indole (177274-67-8) → N-[2-(1-benzenesulfonyl-3-bromo-1H-indole-2-carbonyl)-4-bromo-5-methoxy-phenyl]-acetamide (619297-32-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 78.4 percent / aq. potassium carbonate / acetonitrile / 5 h / Heating

2: 76 percent / BF₃*Et₂O; MgSO₄ / CHCl₃ / 3 h / Heating

3: 61 percent / CrO₃*2Py / pyridine / 48 h / 50 - 60 °C

With boron trifluoride diethyl etherate; dipyridine chromium trioxide; magnesium sulfate; potassium carbonate; In pyridine; chloroform; acetonitrile;

DOI:10.1081/SCC-120021513

Reference yield:

N-(4-bromo-3-methoxyphenyl)acetamide (104066-80-0) → N-[2-(1-benzenesulfonyl-3-bromo-1H-indole-2-carbonyl)-4-bromo-5-methoxy-phenyl]-acetamide (619297-32-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / BF₃*Et₂O; MgSO₄ / CHCl₃ / 3 h / Heating

2: 61 percent / CrO₃*2Py / pyridine / 48 h / 50 - 60 °C

With boron trifluoride diethyl etherate; dipyridine chromium trioxide; magnesium sulfate; In pyridine; chloroform;

DOI:10.1081/SCC-120021513

upstream raw materials:

N-{4-bromo-2-[(3-bromo-1-phenylsulfonyl-1H-indol-2-yl)methyl]-5-methoxyphenyl}acetamide

3-bromo-2-(bromomethyl)-1-(phenylsulfonyl)-1H-indole

N-(4-bromo-3-methoxyphenyl)acetamide

[3-bromo-1-(phenylsulfonyl)indol-2-yl]methanol