N-(3-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide

Base Information

Chemical Name:N-(3-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide
CAS No.:1346447-81-1
Molecular Formula:C₂₂H₂₂ClN₅O₃S
Molecular Weight:471.967
Hs Code.:

Synonyms:N-(3-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide

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Chemical Property of N-(3-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide

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Technology Process of N-(3-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide

There total 8 articles about N-(3-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1346447-80-0
5-chloro-4-N-(2-isopropylsulfonylbenzene)-2-N-(3-aminophenyl)pyrimidine-2,4-diamine

: 814-68-6,25189-84-8
acryloyl chloride

: 1346447-81-1
N-(3-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide

Guidance literature:: In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.ejphar.2021.174297

Reference yield:

: 76697-50-2
1-amino-2-(isopropylsulphonyl)benzene

: 1346447-81-1
N-(3-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / Cooling

1.2: 16 h / 20 °C

2.1: toluene-4-sulfonic acid / isopropyl alcohol / 16 h / 80 °C

3.1: hydrogen / platinum(IV) oxide / ethyl acetate / 2 h

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.02 h / 0 °C

With hydrogen; sodium hydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 70415-85-9
2-(isopropyl sulfanyl)nitrobenzene

: 1346447-81-1
N-(3-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h

3.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / Cooling

3.2: 16 h / 20 °C

4.1: toluene-4-sulfonic acid / isopropyl alcohol / 16 h / 80 °C

5.1: hydrogen / platinum(IV) oxide / ethyl acetate / 2 h

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.02 h / 0 °C

With hydrogen; sodium hydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; platinum(IV) oxide; palladium 10% on activated carbon; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;