5-chloro-4-N-(2-isopropylsulfonylbenzene)-2-N-(3-aminophenyl)pyrimidine-2,4-diamine

Base Information

Chemical Name:5-chloro-4-N-(2-isopropylsulfonylbenzene)-2-N-(3-aminophenyl)pyrimidine-2,4-diamine
CAS No.:1346447-80-0
Molecular Formula:C₁₉H₂₀ClN₅O₂S
Molecular Weight:417.919
Hs Code.:

Synonyms:5-chloro-4-N-(2-isopropylsulfonylbenzene)-2-N-(3-aminophenyl)pyrimidine-2,4-diamine

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Chemical Property of 5-chloro-4-N-(2-isopropylsulfonylbenzene)-2-N-(3-aminophenyl)pyrimidine-2,4-diamine

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Technology Process of 5-chloro-4-N-(2-isopropylsulfonylbenzene)-2-N-(3-aminophenyl)pyrimidine-2,4-diamine

There total 10 articles about 5-chloro-4-N-(2-isopropylsulfonylbenzene)-2-N-(3-aminophenyl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1346447-79-7
5-chloro-N⁴-(2-(isopropylsulfonyl)phenyl)-N²-(3-nitrophenyl)pyrimidine-2,4-diamine

: 1346447-80-0
5-chloro-4-N-(2-isopropylsulfonylbenzene)-2-N-(3-aminophenyl)pyrimidine-2,4-diamine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 2h;

Reference yield: 59.9%

: 761440-16-8
2-chloro-N-(2-(isopropylsulfonyl)phenyl)-5-methyl-pyrimidin-4-amine

: 108-45-2,64554-26-3,76583-20-5
m-phenylenediamine

: 1346447-80-0
5-chloro-4-N-(2-isopropylsulfonylbenzene)-2-N-(3-aminophenyl)pyrimidine-2,4-diamine

Guidance literature:: With hydrogenchloride; In isopropyl alcohol; at 90 ℃; for 6h;
DOI:10.1016/j.ejmech.2021.113672

Reference yield:

: 76697-50-2
1-amino-2-(isopropylsulphonyl)benzene

: 1346447-80-0
5-chloro-4-N-(2-isopropylsulfonylbenzene)-2-N-(3-aminophenyl)pyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / Cooling

1.2: 16 h / 20 °C

2.1: toluene-4-sulfonic acid / isopropyl alcohol / 16 h / 80 °C

3.1: hydrogen / platinum(IV) oxide / ethyl acetate / 2 h

With hydrogen; sodium hydride; toluene-4-sulfonic acid; platinum(IV) oxide; In ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;