1,2-Propanedione, 1-(4-methoxyphenyl)-, 1-oxime

Base Information

• Chemical Name: 1,2-Propanedione, 1-(4-methoxyphenyl)-, 1-oxime
• CAS No.: 36176-47-3
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.202
• Mol file: 36176-47-3.mol

Synonyms:1-hydroxyimino-1-(4-methoxyphenyl)propan-2-one

Chemical Property of 1,2-Propanedione, 1-(4-methoxyphenyl)-, 1-oxime

Chemical Property:

• Boiling Point: 332.3±34.0 °C(Predicted)
• PKA: 8.97±0.11(Predicted)
• Density: 1.14±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(Hydroxyimino)-1-(4-methoxyphenyl)propan-2-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-Propanedione, 1-(4-methoxyphenyl)-, 1-oxime

There total 8 articles about 1,2-Propanedione, 1-(4-methoxyphenyl)-, 1-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-nitro-1-(4-methoxylphenyl) propane (29865-49-4) → 1-(hydroxyimino-(seqtrans))-1-(4-methoxy-phenyl)-acetone (36176-47-3) + 4-methoxybenzonitrile (874-90-8)

Guidance literature:

With acetic acid; sodium nitrite; In dimethyl sulfoxide; at 35 ℃; for 1.5h;

DOI:10.1016/j.tetlet.2003.09.054

Reference yield: 51.2%

4-methoxybenzyl methyl ketone (122-84-9) → 1-hydroxyimino-1-(4-methoxyphenyl)propan-2-one (36176-47-3)

Guidance literature:

With hydrogenchloride; isopentyl nitrite; In diethyl ether; Ambient temperature;

Reference yield: 27.0%

ethyl acetoacetate (141-97-9) + 4-methoxy-aniline (104-94-9) → 1-hydroxyimino-1-(4-methoxyphenyl)propan-2-one (36176-47-3)

Guidance literature:

4-methoxy-aniline; With sulfuric acid; sodium nitrite; In water; Inert atmosphere;

ethyl acetoacetate; With potassium hydroxide; In water; for 3h; Further stages; Inert atmosphere;

DOI:10.1002/ejoc.201300463

upstream raw materials:

p-methoxybenzenediazonium

propanone 1-oxime

4-methoxybenzyl methyl ketone

ethyl acetoacetate

Downstream raw materials:

N-(4-methoxyphenyl)-2-oxopropanamide

4-methoxybenzoic acid

(E,E)-2,5-bis[2-(2-quinolyl)ethenyl]-3,6-bis(4-methoxyphenyl)pyrazine

2,5-bis-methyl-3,6-bis-(4'-methoxyphenyl)-pyrazine

Refernces

• 1、 -. "1,2,5-thiadiazole-2 oxide analogue and application thereof". Paragraph 0062; 0063-0066; 0087; 0088; 0089; 0090; 0091. . Retrieved 2017/07/31.
• 2、 Fitton, Alan O.,Muzanila, Charles N.,Odusanya, Olubunmi M.,Oppong-Boachie, Francis K.,Duckworth, Stephen J.,Hadi, A. Hamid b. A.. "Cyclisation of 1-Aryl-1-benzamidopropan-2-ols. Formation of 4,4-Dihydro-oxazoles, rearranged 4,5-Dihydro-oxazoles and Isoquinolines.". . p. 2701 - 2719. Retrieved 2007/10/02.