3α-[[[[4-(diphenylamino)-1,4-dioxobutyl]amino]acetyl]oxy]-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-5β-cholane

Base Information

Chemical Name:3α-[[[[4-(diphenylamino)-1,4-dioxobutyl]amino]acetyl]oxy]-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-5β-cholane
CAS No.:1367177-65-8
Molecular Formula:C₄₉H₆₉N₃O₆S₂
Molecular Weight:860.235
Hs Code.:

Synonyms:3α-[[[[4-(diphenylamino)-1,4-dioxobutyl]amino]acetyl]oxy]-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-5β-cholane

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Chemical Property of 3α-[[[[4-(diphenylamino)-1,4-dioxobutyl]amino]acetyl]oxy]-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-5β-cholane

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Technology Process of 3α-[[[[4-(diphenylamino)-1,4-dioxobutyl]amino]acetyl]oxy]-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-5β-cholane

There total 3 articles about 3α-[[[[4-(diphenylamino)-1,4-dioxobutyl]amino]acetyl]oxy]-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-5β-cholane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1219923-31-5
3α-aminoacetoxy-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-5β-cholane

: 77778-94-0
4-(N,N-diphenylamino)-4-oxobutanoic acid

: 1367177-65-8
3α-[[[[4-(diphenylamino)-1,4-dioxobutyl]amino]acetyl]oxy]-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-5β-cholane

Guidance literature:: 4-(N,N-diphenylamino)-4-oxobutanoic acid; With benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

3α-aminoacetoxy-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-5β-cholane; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 48h;
DOI:10.1002/hc.21002

Reference yield:

: 77778-93-9
methyl 3-(diphenylaminocarbonyl)propionate

: 1367177-65-8
3α-[[[[4-(diphenylamino)-1,4-dioxobutyl]amino]acetyl]oxy]-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-5β-cholane

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

2.1: benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 0.5 h / 20 °C

2.3: 48 h / 0 - 20 °C

With water; benzotriazol-1-ol; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hc.21002

Reference yield:

: 122-39-4
diphenylamine

: 1367177-65-8
3α-[[[[4-(diphenylamino)-1,4-dioxobutyl]amino]acetyl]oxy]-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-5β-cholane

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 3 h / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

3.1: benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 0.5 h / 20 °C

3.3: 48 h / 0 - 20 °C

With water; benzotriazol-1-ol; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hc.21002