2-amino-4-[2,4-dichloro-6-(2-chloro-ethoxy)-phenyl]-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

Base Information

• Chemical Name: 2-amino-4-[2,4-dichloro-6-(2-chloro-ethoxy)-phenyl]-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide
• CAS No.: 1046861-32-8
• Molecular Formula: C₁₈H₁₈Cl₃N₅O₂
• Molecular Weight: 442.732

Synonyms:2-amino-4-[2,4-dichloro-6-(2-chloro-ethoxy)-phenyl]-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

Chemical Property of 2-amino-4-[2,4-dichloro-6-(2-chloro-ethoxy)-phenyl]-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

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Technology Process of 2-amino-4-[2,4-dichloro-6-(2-chloro-ethoxy)-phenyl]-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

There total 1 articles about 2-amino-4-[2,4-dichloro-6-(2-chloro-ethoxy)-phenyl]-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide (1046861-31-7) + 1-Bromo-2-chloroethane (107-04-0) → 2-amino-4-[2,4-dichloro-6-(2-chloro-ethoxy)-phenyl]-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide (1046861-32-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 12h;

Reference yield: 57.0%

morpholine (110-91-8,99108-56-2) + 2-amino-4-[2,4-dichloro-6-(2-chloro-ethoxy)-phenyl]-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide (1046861-32-8) → 2-amino-N-cyclopropyl-4-[2,4-dichloro-6-(2-morpholin-4-ylethoxy)phenyl]-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide (1046859-25-9)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 120 ℃; for 0.75h; Microwave irradiation;

Reference yield: 48.0%

4-bromo-1H-pyrazole (2075-45-8) + 2-amino-4-[2,4-dichloro-6-(2-chloro-ethoxy)-phenyl]-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide (1046861-32-8) → 2-amino-4-{2-[2-(4-bromo-1H-pyrazol-1-yl)ethoxy]-4,6-dichlorophenyl}-N-cyclopropyl-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide (1207961-36-1)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 130 ℃; for 1h; microwave irradiation;

upstream raw materials:

2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

1-Bromo-2-chloroethane

Downstream raw materials:

2-amino-N-cyclopropyl-4-[2,4-dichloro-6-(2-morpholin-4-ylethoxy)phenyl]-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide

2-amino-4-{2-[2-(4-bromo-1H-pyrazol-1-yl)ethoxy]-4,6-dichlorophenyl}-N-cyclopropyl-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide

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