2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

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Chemical Name:2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide
CAS No.:1046861-31-7
Molecular Formula:C₁₆H₁₅Cl₂N₅O₂
Molecular Weight:380.233
Hs Code.:

Synonyms:2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

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Chemical Property of 2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

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Technology Process of 2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

There total 9 articles about 2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1028332-22-0
(2,4-dichloro-6-hydroxyphenyl)boronic acid

: 1046861-65-7
2-amino-4-iodo-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

: 1046861-31-7
2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 12h; Inert atmosphere;

Reference yield:

: 1028332-19-5
3,5-dichloro-2-iodophenol

: 1046861-31-7
2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: palladium diacetate; triethylamine; CyJohnPhos / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

3.2: Cooling

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 8 h / 85 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; boron tribromide; sodium carbonate; potassium carbonate; triethylamine; CyJohnPhos; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 4.1: Suzuki coupling;
DOI:10.1021/jm200128m

Reference yield:

: 1028332-20-8
1,5-dichloro-3-(ethoxymethoxy)-2-iodobenzene

: 1046861-31-7
2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium diacetate; triethylamine; CyJohnPhos / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

2.2: Cooling

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 8 h / 85 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; boron tribromide; sodium carbonate; triethylamine; CyJohnPhos; In 1,4-dioxane; dichloromethane; 3.1: Suzuki coupling;
DOI:10.1021/jm200128m