2-(3-methoxyphenyl)-7-(4-methylsulfonyl)-4-phenylpyrido[3,2-d]pyrimidine

Base Information

Chemical Name:2-(3-methoxyphenyl)-7-(4-methylsulfonyl)-4-phenylpyrido[3,2-d]pyrimidine
CAS No.:1345955-92-1
Molecular Formula:C₂₇H₂₁N₃O₃S
Molecular Weight:467.548
Hs Code.:

Synonyms:2-(3-methoxyphenyl)-7-(4-methylsulfonyl)-4-phenylpyrido[3,2-d]pyrimidine

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Chemical Property of 2-(3-methoxyphenyl)-7-(4-methylsulfonyl)-4-phenylpyrido[3,2-d]pyrimidine

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Technology Process of 2-(3-methoxyphenyl)-7-(4-methylsulfonyl)-4-phenylpyrido[3,2-d]pyrimidine

There total 5 articles about 2-(3-methoxyphenyl)-7-(4-methylsulfonyl)-4-phenylpyrido[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1345955-88-5
7-chloro-2-(3-methoxyphenyl)-4-phenyl-pyrido[3,2-d]pyrimidine

: 149104-88-1
4-methanesulphonylphenylboronic acid

: 1345955-92-1
2-(3-methoxyphenyl)-7-(4-methylsulfonyl)-4-phenylpyrido[3,2-d]pyrimidine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 150 ℃; for 0.166667h; regioselective reaction; Inert atmosphere; Microwave irradiation;
DOI:10.1002/ejoc.201200521

Reference yield:

: 1260663-38-4
2,4,7-trichloropyrido[3,2-d]pyrimidine

: 1345955-92-1
2-(3-methoxyphenyl)-7-(4-methylsulfonyl)-4-phenylpyrido[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene / 2 h / 100 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 4 h / 100 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene / 0.17 h / 150 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; In ethanol; toluene; 1: |Suzuki Coupling / 2: |Suzuki Coupling / 3: |Suzuki Coupling;
DOI:10.1002/ejoc.201200521

Reference yield:

: 1345955-85-2
2,7-dichloro-4-phenyl-pyrido[3,2-d]pyrimidine

: 1345955-92-1
2-(3-methoxyphenyl)-7-(4-methylsulfonyl)-4-phenylpyrido[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 4 h / 100 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene / 0.17 h / 150 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; In ethanol; toluene; 1: |Suzuki Coupling / 2: |Suzuki Coupling;
DOI:10.1002/ejoc.201200521