(1-METHYL-1H-BENZIMIDAZOL-2-YL)METHYLAMINE DIHYDROCHLORIDE

Base Information

• Chemical Name: (1-METHYL-1H-BENZIMIDAZOL-2-YL)METHYLAMINE DIHYDROCHLORIDE
• CAS No.: 53332-79-9
• Molecular Formula: C₉H₁₁N₃*2ClH
• Molecular Weight: 234.128
• Mol file: 53332-79-9.mol

Synonyms:2-aminomethyl-1-methylbenzimidazole dihydrochloride

Chemical Property of (1-METHYL-1H-BENZIMIDAZOL-2-YL)METHYLAMINE DIHYDROCHLORIDE

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

[(1-methyl-1H-benzimidazol-2-yl)methyl]aminedihydrochloride 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

• Uses: (1-Methyl-1H-benzo[d]imidazol-2-yl)methanamine Dihydrochloride is used in the synthesis of benzimidazolyl Schiff base ligands.

Technology Process of (1-METHYL-1H-BENZIMIDAZOL-2-YL)METHYLAMINE DIHYDROCHLORIDE

There total 3 articles about (1-METHYL-1H-BENZIMIDAZOL-2-YL)METHYLAMINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-methyl-1H-benzo[d]imidazole-2-carbaldehyde oxime (3013-07-8) → 2-aminomethyl-1-methylbenzimidazole dihydrochloride (53332-79-9)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In ethanol; for 2h; under 2327.23 Torr; Acidic conditions;

Reference yield:

glycine (56-40-6,18875-39-3,25718-94-9) + N-methyl-1,2-phenylenediamine (4760-34-3) → 2-aminomethyl-1-methylbenzimidazole dihydrochloride (53332-79-9)

Guidance literature:

With hydrogenchloride; In water; for 90h; Heating / reflux;

Reference yield:

EtOH-water + glycine (56-40-6,18875-39-3,25718-94-9) + N-methyl-1,2-phenylenediamine (4760-34-3) → 2-aminomethyl-1-methylbenzimidazole dihydrochloride (53332-79-9)

Guidance literature:

In hydrogenchloride; ethanol; water;

upstream raw materials:

1-methyl-1H-benzo[d]imidazole-2-carbaldehyde oxime

glycine

N-methyl-1,2-phenylenediamine

Downstream raw materials:

C-(1-methyl-1H-benzoimidazol-2-yl)-methylamine

HOC₆H₂(C(CH₃)3)2CHNCH₂C₇H₄N₂CH₃

Refernces

• 1、 -. "2-(1H-INDAZOL-6-YLAMINO)-BENZAMIDE COMPOUNDS AS PROTEIN KINASES INHIBITORS USEFUL FOR THE TREATMENT OF OPHTALMIC DISEASES". Page 73. . Retrieved 2010/02/07.