(R)-4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoic acid

Base Information

Chemical Name:(R)-4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoic acid
CAS No.:1608471-45-9
Molecular Formula:C₂₅H₂₇N₃O₃
Molecular Weight:417.508
Hs Code.:

Synonyms:(R)-4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoic acid

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Chemical Property of (R)-4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoic acid

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Technology Process of (R)-4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoic acid

There total 4 articles about (R)-4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1637740-91-0
(R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoate

: 1608471-45-9
(R)-4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoic acid

Guidance literature:: (R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoate; With lithium hydroxide; In tetrahydrofuran; water; at 50 ℃; for 16h;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; pH=4;
DOI:10.1021/jm500206r

Reference yield:

: 18179-39-0
methyl 4-iodosalicylate

: 1608471-45-9
(R)-4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 0 - 20 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,2-dimethoxyethane / 80 °C / Inert atmosphere

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 16 h / 70 °C / Inert atmosphere

4.1: lithium hydroxide / tetrahydrofuran; water / 16 h / 50 °C

4.2: 20 °C / pH 4

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 3.1: |Suzuki Coupling;
DOI:10.1021/jm500206r

Reference yield:

: 851334-98-0
methyl 2-ethoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: 1608471-45-9
(R)-4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 16 h / 70 °C / Inert atmosphere

2.1: lithium hydroxide / tetrahydrofuran; water / 16 h / 50 °C

2.2: 20 °C / pH 4

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1.1: |Suzuki Coupling;
DOI:10.1021/jm500206r