(R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoate

Base Information

Chemical Name:(R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoate
CAS No.:1637740-91-0
Molecular Formula:C₂₆H₂₉N₃O₃
Molecular Weight:431.535
Hs Code.:

Synonyms:(R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoate

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Chemical Property of (R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoate

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Technology Process of (R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoate

There total 2 articles about (R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 851334-98-0
methyl 2-ethoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: 1246765-10-5
(R)-4-(3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl)-2-methylbenzonitrile

: 1637740-91-0
(R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; at 70 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm500206r

Reference yield:

: 1246765-31-0
methyl 2-ethoxy-4-iodobenzoate

: 1637740-91-0
(R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,2-dimethoxyethane / 80 °C / Inert atmosphere

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 16 h / 70 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; In 1,2-dimethoxyethane; 2: |Suzuki Coupling;
DOI:10.1021/jm500206r

Reference yield: 90.0%

: 1637740-91-0
(R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoate

: 1608471-45-9
(R)-4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoic acid

Guidance literature:: (R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxybenzoate; With lithium hydroxide; In tetrahydrofuran; water; at 50 ℃; for 16h;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; pH=4;
DOI:10.1021/jm500206r