4,11-bis-{4-[13-(2,2,2-trichloro-ethoxycarbonyl)-1,9-dithia-5,13-diaza-cyclohexadec-5-ylmethyl]-benzoyl}-1,4,8,11tetraaza-cyclotetradecane-1,8-dicarboxylic acid di-tert-butyl ester

Base Information

Chemical Name:4,11-bis-{4-[13-(2,2,2-trichloro-ethoxycarbonyl)-1,9-dithia-5,13-diaza-cyclohexadec-5-ylmethyl]-benzoyl}-1,4,8,11tetraaza-cyclotetradecane-1,8-dicarboxylic acid di-tert-butyl ester
CAS No.:890706-84-0
Molecular Formula:C₆₆H₁₀₂Cl₆N₈O₁₀S₄
Molecular Weight:1508.57
Hs Code.:

4,11-bis-{4-[13-(2,2,2-trichloro-ethoxycarbonyl)-1,9-dithia-5,13-diaza-cyclohexadec-5-ylmethyl]-benzoyl}-1,4,8,11tetraaza-cyclotetradecane-1,8-dicarboxylic acid di-<i>tert</i>-butyl ester

Synonyms:4,11-bis-{4-[13-(2,2,2-trichloro-ethoxycarbonyl)-1,9-dithia-5,13-diaza-cyclohexadec-5-ylmethyl]-benzoyl}-1,4,8,11tetraaza-cyclotetradecane-1,8-dicarboxylic acid di-tert-butyl ester

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Chemical Property of 4,11-bis-{4-[13-(2,2,2-trichloro-ethoxycarbonyl)-1,9-dithia-5,13-diaza-cyclohexadec-5-ylmethyl]-benzoyl}-1,4,8,11tetraaza-cyclotetradecane-1,8-dicarboxylic acid di-tert-butyl ester

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Technology Process of 4,11-bis-{4-[13-(2,2,2-trichloro-ethoxycarbonyl)-1,9-dithia-5,13-diaza-cyclohexadec-5-ylmethyl]-benzoyl}-1,4,8,11tetraaza-cyclotetradecane-1,8-dicarboxylic acid di-tert-butyl ester

There total 4 articles about 4,11-bis-{4-[13-(2,2,2-trichloro-ethoxycarbonyl)-1,9-dithia-5,13-diaza-cyclohexadec-5-ylmethyl]-benzoyl}-1,4,8,11tetraaza-cyclotetradecane-1,8-dicarboxylic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 180966-00-1
5-(2,2,2-trichloroethoxycarbonyl)-1,9-dithia-5,13-diazacyclohexadecane

: 414858-13-2
1,8-bis(tert-butoxycarbonyl)-4,11-bis[4-(chloromethyl)benzoyl]-1,4,8,11-tetraazacyclotetradecane

: 890706-84-0
4,11-bis-{4-[13-(2,2,2-trichloro-ethoxycarbonyl)-1,9-dithia-5,13-diaza-cyclohexadec-5-ylmethyl]-benzoyl}-1,4,8,11tetraaza-cyclotetradecane-1,8-dicarboxylic acid di-tert-butyl ester

Guidance literature:: With sodium carbonate; In acetonitrile; for 24h; Heating;
DOI:10.1016/j.tet.2006.02.012

Reference yield:

: 866414-15-5
1,8-dibenzyl-4,11-bis(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

: 890706-84-0
4,11-bis-{4-[13-(2,2,2-trichloro-ethoxycarbonyl)-1,9-dithia-5,13-diaza-cyclohexadec-5-ylmethyl]-benzoyl}-1,4,8,11tetraaza-cyclotetradecane-1,8-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / glacial acetic acid; hydrogen / palladium on charcoal / methanol / 12 h / 2280 Torr

2: 95 percent / triethylamine / CH₂Cl₂ / 12 h / 20 °C

3: 87 percent / sodium carbonate / acetonitrile / 24 h / Heating

With hydrogen; sodium carbonate; acetic acid; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2006.02.012

Reference yield:

: 876-08-4
p-(chloromethyl)benzoyl chloride

: 890706-84-0
4,11-bis-{4-[13-(2,2,2-trichloro-ethoxycarbonyl)-1,9-dithia-5,13-diaza-cyclohexadec-5-ylmethyl]-benzoyl}-1,4,8,11tetraaza-cyclotetradecane-1,8-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / triethylamine / CH₂Cl₂ / 12 h / 20 °C

2: 87 percent / sodium carbonate / acetonitrile / 24 h / Heating

With sodium carbonate; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2006.02.012