414858-13-2Relevant academic research and scientific papers
New heterotopic, linked macrocyclic systems derived from selectively protected macrocycles
Chartres, Jy D.,Lindoy, Leonard F.,Meehan, George V.
, p. 4173 - 4187 (2007/10/03)
The use of orthogonally protected cyclam and 1,9-dithia-5,13-diazacyclohexadecane macrocycles, in combination with aza-18-crown-6, has enabled the efficient synthesis of a new heterotritopic macrocyclic ligand incorporating N4-, N2S
New macrocyclic ligands. XIII single-ring and tri-linked macrocyclic systems derived from selectively protected cyclam
Dong,Lindoy
, p. 291 - 297 (2007/10/03)
The synthesis of the four single-ring cyclam derivatives together with the related tri-linked ring derivatives and tetrabenzylated derivative was reported. In the synthesis, differential Boc-protected cyclam derivatives were used as key intermediates. Benzylated and tri-linked cyclam products were found to rely heavily on high-resolution mass spectrometry (HRMS) and all compounds yielded satisfactory HRMS data.
