Cyclohexanol, 4-(4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl)-, trans-

Base Information

Chemical Name:Cyclohexanol, 4-(4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl)-, trans-
CAS No.:193551-21-2
Molecular Formula:C20H21FN4O2
Molecular Weight:368.411
Hs Code.:2933599590
UNII:HII3DC8CPI
DSSTox Substance ID:DTXSID90274455
Nikkaji Number:J1.314.706J,J1.650.267G
Wikidata:Q27163223,Q27162643
Pharos Ligand ID:WTMP4X3NAJ9N,WTMXZDDFMR1M
ChEMBL ID:CHEMBL97162,CHEMBL256835,CHEMBL4166018
Mol file:193551-21-2.mol

Synonyms:SB 239063;SB-239063;trans-1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole

Suppliers and Price of Cyclohexanol, 4-(4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl)-, trans-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
SB 239063
100mg
$ 1932.00

TRC
SB 239063
5mg
$ 145.00

Tocris
SB 239063 ≥98%(HPLC)
10
$ 300.00

TCI Chemical
SB 239063
25MG
$ 644.00

TCI Chemical
SB 239063
5MG
$ 197.00

Sigma-Aldrich
SB 239063 >98% (HPLC)
5mg
$ 180.00

Sigma-Aldrich
SB 239063
500ug
$ 158.00

Sigma-Aldrich
SB 239063 - CAS 798558-40-4 - Calbiochem A potent, cell-permeable, reversible, and ATP-competitive inhibitor of the α- and β-isoforms (IC?? = 44 nM), but not the γ- or δ-isoform (IC?? > 100 μM), of MAP kinase p38.
500 μg
$ 151.70

Sigma-Aldrich
SB 239063 >98% (HPLC)
25mg
$ 714.00

DC Chemicals
SB 239063 >98%
1 g
$ 2300.00

Total 28 raw suppliers

Chemical Property of Cyclohexanol, 4-(4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl)-, trans-

Chemical Property:

Vapor Pressure:5.42E-15mmHg at 25°C
Melting Point:206-207.2?°C
Boiling Point:594.8°C at 760 mmHg
Flash Point:313.5°C
PSA：73.06000
Density:1.35g/cm³
LogP:3.63080
Storage Temp.:2-8°C
Solubility.:DMSO: 11 mg/mL
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:368.16485409
Heavy Atom Count:27
Complexity:469

Purity/Quality:

99%, ^*data from raw suppliers

SB 239063 ^*data from reagent suppliers

Safty Information:

Pictogram(s): A poison by ingestion.
Hazard Codes:A poison by ingestion.
Safety Statements: 22-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=NC=CC(=N1)C2=C(N=CN2C3CCC(CC3)O)C4=CC=C(C=C4)F
Uses SB239063 is neuroprotective, decreases the number of activated microglia and facilitates neurogenesis in oxygen-glucose-deprived hippocampal slice cultures. A protein kinase inhibitor SB 239063 has been used to determine the roles of c-Jun N-terminal kinase (JNK), p38 MAP kinase, and extracellular signal regulated protein kinase (ERK)/p42/p44 mitogen activated protein kinase (MAPK) on the viability and apoptosis of cardiomyocytes under glutathione S-transferase (GST) inhibition. It has also been used in neuron-microglia conditioned media (CM) experiments and pharmacokinetics.

Technology Process of Cyclohexanol, 4-(4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl)-, trans-

There total 4 articles about Cyclohexanol, 4-(4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl)-, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%