1,2,3,4-tetrahydro-N-methanesulfonyl-6-methoxy-1-(3,4-dimethoxy-benzyl)-7-phenylmethoxyisoquinoline

Base Information

Chemical Name:1,2,3,4-tetrahydro-N-methanesulfonyl-6-methoxy-1-(3,4-dimethoxy-benzyl)-7-phenylmethoxyisoquinoline
CAS No.:263360-62-9
Molecular Formula:C₂₇H₃₁NO₆S
Molecular Weight:497.612
Hs Code.:

Synonyms:1,2,3,4-tetrahydro-N-methanesulfonyl-6-methoxy-1-(3,4-dimethoxy-benzyl)-7-phenylmethoxyisoquinoline

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Chemical Property of 1,2,3,4-tetrahydro-N-methanesulfonyl-6-methoxy-1-(3,4-dimethoxy-benzyl)-7-phenylmethoxyisoquinoline

Chemical Property:

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Technology Process of 1,2,3,4-tetrahydro-N-methanesulfonyl-6-methoxy-1-(3,4-dimethoxy-benzyl)-7-phenylmethoxyisoquinoline

There total 1 articles about 1,2,3,4-tetrahydro-N-methanesulfonyl-6-methoxy-1-(3,4-dimethoxy-benzyl)-7-phenylmethoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 59444-68-7
(+/-)-7-benzyloxy-6-methoxy-1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

: 124-63-0
methanesulfonyl chloride

: 263360-62-9
1,2,3,4-tetrahydro-N-methanesulfonyl-6-methoxy-1-(3,4-dimethoxy-benzyl)-7-phenylmethoxyisoquinoline

Guidance literature:: With potassium carbonate; In dichloromethane; at 25 ℃; for 1.5h;
DOI:10.3987/COM-99-S84

Reference yield: 89.0%

: 263360-62-9
1,2,3,4-tetrahydro-N-methanesulfonyl-6-methoxy-1-(3,4-dimethoxy-benzyl)-7-phenylmethoxyisoquinoline

: 263360-71-0
1,2,3,4-tetrahydro-N-methanesulfonyl-6-methoxy-1-(3,4-dimethoxy-benzyl)-isoquinolin-7-ol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 25 ℃; for 3h; under 760 Torr;
DOI:10.3987/COM-99-S84

Reference yield:

: 263360-62-9
1,2,3,4-tetrahydro-N-methanesulfonyl-6-methoxy-1-(3,4-dimethoxy-benzyl)-7-phenylmethoxyisoquinoline

: 263360-68-5
6-acetoxy-1,2,3,4,6,7-hexahydro-N-methanesulfonyl-6-methoxy-1-(3,4-dimethoxy-benzyl)-7-oxoisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / H₂ / 10 percent Pd-C / ethyl acetate / 3 h / 25 °C / 760 Torr

2: 100 percent / CH₂Cl₂ / 0.5 h

With hydrogen; palladium on activated charcoal; In dichloromethane; ethyl acetate; 1: debenzylation / 2: Oxidation;
DOI:10.3987/COM-99-S84