methyl (2S,3R)-4-[(2S,6R)-2-(2-tert-butyldimethylsilyloxy-1,1-dimethylethyl)-2,3-dihydro-6H-pyran-6-yl]-3-methoxy-2-(4-methoxybenzyloxy)butyrate

Base Information

Chemical Name:methyl (2S,3R)-4-[(2S,6R)-2-(2-tert-butyldimethylsilyloxy-1,1-dimethylethyl)-2,3-dihydro-6H-pyran-6-yl]-3-methoxy-2-(4-methoxybenzyloxy)butyrate
CAS No.:1346653-57-3
Molecular Formula:C₂₉H₄₈O₇Si
Molecular Weight:536.781
Hs Code.:

Synonyms:methyl (2S,3R)-4-[(2S,6R)-2-(2-tert-butyldimethylsilyloxy-1,1-dimethylethyl)-2,3-dihydro-6H-pyran-6-yl]-3-methoxy-2-(4-methoxybenzyloxy)butyrate

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Chemical Property of methyl (2S,3R)-4-[(2S,6R)-2-(2-tert-butyldimethylsilyloxy-1,1-dimethylethyl)-2,3-dihydro-6H-pyran-6-yl]-3-methoxy-2-(4-methoxybenzyloxy)butyrate

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Technology Process of methyl (2S,3R)-4-[(2S,6R)-2-(2-tert-butyldimethylsilyloxy-1,1-dimethylethyl)-2,3-dihydro-6H-pyran-6-yl]-3-methoxy-2-(4-methoxybenzyloxy)butyrate

There total 1 articles about methyl (2S,3R)-4-[(2S,6R)-2-(2-tert-butyldimethylsilyloxy-1,1-dimethylethyl)-2,3-dihydro-6H-pyran-6-yl]-3-methoxy-2-(4-methoxybenzyloxy)butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1346653-49-3
(4S)-4-benzyl-3-{(2S,3R)-4-[(2S,6R)-2-(2-tertbutyldimethylsilyloxy-1,1-dimethylethyl)-2,3-dihydro-6H-pyran-6-yl]-3-methoxy-2-(4-methoxybenzyloxy)-1-oxobutyl}-oxazolidin-2-one

: 124-41-4
sodium methylate

: 1346653-57-3
methyl (2S,3R)-4-[(2S,6R)-2-(2-tert-butyldimethylsilyloxy-1,1-dimethylethyl)-2,3-dihydro-6H-pyran-6-yl]-3-methoxy-2-(4-methoxybenzyloxy)butyrate

Guidance literature:: With carbonic acid dimethyl ester; In dichloromethane; at 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1016/j.tet.2011.09.131

Reference yield: 62.0%

: 1346653-57-3
methyl (2S,3R)-4-[(2S,6R)-2-(2-tert-butyldimethylsilyloxy-1,1-dimethylethyl)-2,3-dihydro-6H-pyran-6-yl]-3-methoxy-2-(4-methoxybenzyloxy)butyrate

: 1346653-58-4
methyl (2S,3R)-4-[(2S,6R)-(2-hydroxy-1,1-dimethylethyl)-2,3-dihydro-6H-pyran-6-yl]-3-methoxy-2-(4-methoxybenzyloxy)butyrate

Guidance literature:: With hydrogenchloride; In methanol; dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2011.09.131

Reference yield:

: 1346653-57-3
methyl (2S,3R)-4-[(2S,6R)-2-(2-tert-butyldimethylsilyloxy-1,1-dimethylethyl)-2,3-dihydro-6H-pyran-6-yl]-3-methoxy-2-(4-methoxybenzyloxy)butyrate

: C₂₃H₃₂O₇

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / methanol; dichloromethane / 20 °C / Inert atmosphere

2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / Inert atmosphere

With hydrogenchloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; In methanol; dichloromethane;
DOI:10.1016/j.tet.2011.09.131