6-(4-fluorophenyl)-2-{2-[(2S)-2-methylpyrrolidin-1-yl]ethyl}-3,4-dihydroisoquinolin-1(2H)-one hydrochloride

Base Information

Chemical Name:6-(4-fluorophenyl)-2-{2-[(2S)-2-methylpyrrolidin-1-yl]ethyl}-3,4-dihydroisoquinolin-1(2H)-one hydrochloride
CAS No.:1131216-04-0
Molecular Formula:C₂₂H₂₅FN₂O*ClH
Molecular Weight:388.913
Hs Code.:

Synonyms:6-(4-fluorophenyl)-2-{2-[(2S)-2-methylpyrrolidin-1-yl]ethyl}-3,4-dihydroisoquinolin-1(2H)-one hydrochloride

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Chemical Property of 6-(4-fluorophenyl)-2-{2-[(2S)-2-methylpyrrolidin-1-yl]ethyl}-3,4-dihydroisoquinolin-1(2H)-one hydrochloride

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Technology Process of 6-(4-fluorophenyl)-2-{2-[(2S)-2-methylpyrrolidin-1-yl]ethyl}-3,4-dihydroisoquinolin-1(2H)-one hydrochloride

There total 5 articles about 6-(4-fluorophenyl)-2-{2-[(2S)-2-methylpyrrolidin-1-yl]ethyl}-3,4-dihydroisoquinolin-1(2H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1131222-81-5
2-(6-(4-fluorophenyl)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)acetaldehyde

: 765-38-8,41720-98-3,59335-84-1,79171-53-2
(S)-2-methylpyrrolidine

: 1131216-04-0
6-(4-fluorophenyl)-2-{2-[(2S)-2-methylpyrrolidin-1-yl]ethyl}-3,4-dihydroisoquinolin-1(2H)-one hydrochloride

Guidance literature:: 2-(6-(4-fluorophenyl)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)acetaldehyde; (S)-2-methylpyrrolidine; With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃;

With hydrogenchloride; In diethyl ether; ethanol; water;
DOI:10.1021/jm300011d

Reference yield:

: 147497-32-3
6-bromo-3,4-dihydroisoquinolin-1(2H)-one

: 1131216-04-0
6-(4-fluorophenyl)-2-{2-[(2S)-2-methylpyrrolidin-1-yl]ethyl}-3,4-dihydroisoquinolin-1(2H)-one hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.58 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: dichlorobis(tri-O-tolylphosphine)palladium; potassium carbonate / 1,4-dioxane; water / 0.5 h / 90 °C

3.1: sodium periodate / tetrahydrofuran; water / 0.17 h / 0 °C

3.2: 8 h / 0 °C

4.1: sodium cyanoborohydride; acetic acid / methanol / 20 °C

With sodium periodate; dichlorobis(tri-O-tolylphosphine)palladium; sodium hydride; sodium cyanoborohydride; potassium carbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; mineral oil; 2.1: Suzuki coupling;
DOI:10.1021/jm300011d

Reference yield:

: 1131222-49-5
2-allyl-6-bromo-3,4-dihydroisoquinolin-1(2H)-one

: 1131216-04-0
6-(4-fluorophenyl)-2-{2-[(2S)-2-methylpyrrolidin-1-yl]ethyl}-3,4-dihydroisoquinolin-1(2H)-one hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichlorobis(tri-O-tolylphosphine)palladium; potassium carbonate / 1,4-dioxane; water / 0.5 h / 90 °C

2.1: sodium periodate / tetrahydrofuran; water / 0.17 h / 0 °C

2.2: 8 h / 0 °C

3.1: sodium cyanoborohydride; acetic acid / methanol / 20 °C

With sodium periodate; dichlorobis(tri-O-tolylphosphine)palladium; sodium cyanoborohydride; potassium carbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1.1: Suzuki coupling;
DOI:10.1021/jm300011d