2-(6-(4-fluorophenyl)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)acetaldehyde

Base Information

Chemical Name:2-(6-(4-fluorophenyl)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)acetaldehyde
CAS No.:1131222-81-5
Molecular Formula:C₁₇H₁₄FNO₂
Molecular Weight:283.302
Hs Code.:

Synonyms:2-(6-(4-fluorophenyl)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)acetaldehyde

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Chemical Property of 2-(6-(4-fluorophenyl)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)acetaldehyde

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Technology Process of 2-(6-(4-fluorophenyl)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)acetaldehyde

There total 5 articles about 2-(6-(4-fluorophenyl)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1131222-57-5
2-allyl-6-(4-fluorophenyl)-3,4-dihydroisoquinolin-1(2H)-one

: 1131222-81-5
2-(6-(4-fluorophenyl)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)acetaldehyde

Guidance literature:: 2-allyl-6-(4-fluorophenyl)-3,4-dihydroisoquinolin-1(2H)-one; With sodium periodate; In tetrahydrofuran; water; at 0 ℃; for 0.166667h;

With osmium(VIII) oxide; In tetrahydrofuran; water; at 0 ℃; for 8h;
DOI:10.1021/jm300011d

Reference yield: 97.0%

: 1131222-81-5
2-(6-(4-fluorophenyl)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)acetaldehyde

Guidance literature:

Reference yield:

: 147497-32-3
6-bromo-3,4-dihydroisoquinolin-1(2H)-one

: 1131222-81-5
2-(6-(4-fluorophenyl)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)acetaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.58 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: dichlorobis(tri-O-tolylphosphine)palladium; potassium carbonate / 1,4-dioxane; water / 0.5 h / 90 °C

3.1: sodium periodate / tetrahydrofuran; water / 0.17 h / 0 °C

3.2: 8 h / 0 °C

With sodium periodate; dichlorobis(tri-O-tolylphosphine)palladium; sodium hydride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil; 2.1: Suzuki coupling;
DOI:10.1021/jm300011d