2,6-Dichloro-5-fluoro-N-(2-hydroxy-1,1-dimethyl-ethyl)-nicotinamide

Base Information

Chemical Name:2,6-Dichloro-5-fluoro-N-(2-hydroxy-1,1-dimethyl-ethyl)-nicotinamide
CAS No.:182867-99-8
Molecular Formula:C₁₀H₁₁Cl₂FN₂O₂
Molecular Weight:281.114
Hs Code.:

Synonyms:2,6-Dichloro-5-fluoro-N-(2-hydroxy-1,1-dimethyl-ethyl)-nicotinamide

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Chemical Property of 2,6-Dichloro-5-fluoro-N-(2-hydroxy-1,1-dimethyl-ethyl)-nicotinamide

Chemical Property:

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Technology Process of 2,6-Dichloro-5-fluoro-N-(2-hydroxy-1,1-dimethyl-ethyl)-nicotinamide

There total 1 articles about 2,6-Dichloro-5-fluoro-N-(2-hydroxy-1,1-dimethyl-ethyl)-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82671-06-5
2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid

: 182867-99-8
2,6-Dichloro-5-fluoro-N-(2-hydroxy-1,1-dimethyl-ethyl)-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / SOCl₂, DMF / toluene / 3 h / 85 °C

2: 96 percent / CH₂Cl₂ / 3 h / Ambient temperature

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; toluene;
DOI:10.1016/0968-0896(96)00106-X

Reference yield:

: 182867-99-8
2,6-Dichloro-5-fluoro-N-(2-hydroxy-1,1-dimethyl-ethyl)-nicotinamide

: 182868-20-8
C₂₈H₃₀ClN₃O₆

Guidance literature:: Multi-step reaction with 10 steps

1: 87 percent / SOCl₂ / CH₂Cl₂ / 22.5 h / Ambient temperature

2: 1.) LDA / 1.) THF, -78 deg C, 15 min, 2.) THF, 0 deg C, 30 min

3: 66 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

4: 45 percent / NaH / tetrahydrofuran / Heating

5: 10percent aq. HCl / 22 h / 90 - 95 °C

6: dioxane / 1 h / Ambient temperature

7: 100 percent / SOCl₂, DMF / 2.5 h / Ambient temperature

8: 1.) LDA / 1.) -78 deg C, 2.) from -78 deg C to 0 deg C

9: Ac₂O / Heating

10: CH₂Cl₂ / 2 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; acetic anhydride; sodium hydride; N,N-dimethyl-formamide; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane;
DOI:10.1016/0968-0896(96)00106-X

Reference yield:

: 182867-99-8
2,6-Dichloro-5-fluoro-N-(2-hydroxy-1,1-dimethyl-ethyl)-nicotinamide

: 182868-26-4
C₃₁H₂₇F₂N₃O₆

Guidance literature:: Multi-step reaction with 11 steps

1: 87 percent / SOCl₂ / CH₂Cl₂ / 22.5 h / Ambient temperature

2: 1.) LDA / 1.) THF, -78 deg C, 15 min, 2.) THF, 0 deg C, 30 min

3: 66 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

4: 45 percent / NaH / tetrahydrofuran / Heating

5: 10percent aq. HCl / 22 h / 90 - 95 °C

6: dioxane / 1 h / Ambient temperature

7: 100 percent / SOCl₂, DMF / 2.5 h / Ambient temperature

8: 1.) LDA / 1.) -78 deg C, 2.) from -78 deg C to 0 deg C

9: Ac₂O / Heating

10: CH₂Cl₂ / 2 h / Ambient temperature

11: 47 percent / NaH / tetrahydrofuran / 0.83 h / 45 - 50 °C

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; acetic anhydride; sodium hydride; N,N-dimethyl-formamide; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane;
DOI:10.1016/0968-0896(96)00106-X