Technology Process of 3-chloro-5,6-dimethoxy-2-(4-methoxyphenyl)benzofuran
There total 4 articles about 3-chloro-5,6-dimethoxy-2-(4-methoxyphenyl)benzofuran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)ethane-1,2-dione;
With
titanium tetrachloride;
In
dichloromethane;
at 20 ℃;
for 0.0166667h;
Inert atmosphere;
With
molybdenum(V) chloride;
In
dichloromethane;
Inert atmosphere;
DOI:10.1021/ol300948u
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / N,N-dimethyl-formamide / 16 h / 81 °C / Inert atmosphere
2.1: potassium permanganate; sodium hydrogencarbonate; magnesium sulfate / water; acetone / 24 h / 20 °C
3.1: titanium tetrachloride / dichloromethane / 0.02 h / 20 °C / Inert atmosphere
3.2: Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; potassium permanganate; copper(l) iodide; titanium tetrachloride; sodium hydrogencarbonate; magnesium sulfate; diisopropylamine;
In
dichloromethane; water; N,N-dimethyl-formamide; acetone;
1.1: Sonogashira coupling / 3.1: Nazarov-type reaction / 3.2: Nazarov-type reaction;
DOI:10.1021/ol300948u
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium permanganate; sodium hydrogencarbonate; magnesium sulfate / water; acetone / 24 h / 20 °C
2.1: titanium tetrachloride / dichloromethane / 0.02 h / 20 °C / Inert atmosphere
2.2: Inert atmosphere
With
potassium permanganate; titanium tetrachloride; sodium hydrogencarbonate; magnesium sulfate;
In
dichloromethane; water; acetone;
2.1: Nazarov-type reaction / 2.2: Nazarov-type reaction;
DOI:10.1021/ol300948u
