methyl 4-(4-fluorophenyl)-2-isopropyl-1,4,4a,5,6,7-hexahydro-[1,8]naphthyridine-3-carboxylate

Base Information

• Chemical Name: methyl 4-(4-fluorophenyl)-2-isopropyl-1,4,4a,5,6,7-hexahydro-[1,8]naphthyridine-3-carboxylate
• CAS No.: 853181-28-9
• Molecular Formula: C₁₉H₂₃FN₂O₂
• Molecular Weight: 330.402

Synonyms:methyl 4-(4-fluorophenyl)-2-isopropyl-1,4,4a,5,6,7-hexahydro-[1,8]naphthyridine-3-carboxylate

Chemical Property of methyl 4-(4-fluorophenyl)-2-isopropyl-1,4,4a,5,6,7-hexahydro-[1,8]naphthyridine-3-carboxylate

Chemical Property:

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Technology Process of methyl 4-(4-fluorophenyl)-2-isopropyl-1,4,4a,5,6,7-hexahydro-[1,8]naphthyridine-3-carboxylate

There total 3 articles about methyl 4-(4-fluorophenyl)-2-isopropyl-1,4,4a,5,6,7-hexahydro-[1,8]naphthyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-(4-fluorophenyl)-4a,5,6,7-tetrahydro-2-(1-methylethyl)-4H-pyrano[2,3-b]pyridine-3-carboxylate (853182-65-7) → methyl 4-(4-fluorophenyl)-2-isopropyl-1,4,4a,5,6,7-hexahydro-[1,8]naphthyridine-3-carboxylate (853181-28-9)

Guidance literature:

With ammonium acetate; In methanol; at 55 ℃; for 2h;

Reference yield:

4-(4-fluorophenyl)-3-(1-oxo-2-methylpropyl)-3,4,4a,5,6,7-hexahydro-1,8-naphthyridin-2(1H)-one (853182-68-0) → methyl 4-(4-fluorophenyl)-2-isopropyl-1,4,4a,5,6,7-hexahydro-[1,8]naphthyridine-3-carboxylate (853181-28-9)

Guidance literature:

With ammonium acetate; In methanol; at 65 - 70 ℃; for 7h;

Reference yield:

methyl 2-[(4-fluorophenyl)-(2-methoxy-3,4,5,6-tetrahydro-pyridin-3-yl)-methyl]-4-methyl-3-oxo-pentanoate (853181-56-3) → methyl 4-(4-fluorophenyl)-2-isopropyl-1,4,4a,5,6,7-hexahydro-[1,8]naphthyridine-3-carboxylate (853181-28-9)

Guidance literature:

With ammonium chloride; In methanol; for 5.5h; Heating / reflux;

upstream raw materials:

methyl 4-(4-fluorophenyl)-4a,5,6,7-tetrahydro-2-(1-methylethyl)-4H-pyrano[2,3-b]pyridine-3-carboxylate

4-(4-fluorophenyl)-3-(1-oxo-2-methylpropyl)-3,4,4a,5,6,7-hexahydro-1,8-naphthyridin-2(1H)-one

methyl 2-[(4-fluorophenyl)-(2-methoxy-3,4,5,6-tetrahydro-pyridin-3-yl)-methyl]-4-methyl-3-oxo-pentanoate

Downstream raw materials:

methyl 4-(4-fluorophenyl)-2-isopropyl-8-methanesulfonyl-4,4a,5,6,7,8-hexahydro-[1,8]naphthyridine-3-carboxylate

methyl 4-(4-fluorophenyl)-2-isopropyl-8-methanesulfonyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate

N,N-diisopropylethylamine hydrochloride

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