methyl 4-(4-fluorophenyl)-2-isopropyl-8-methanesulfonyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate

Base Information

Chemical Name:methyl 4-(4-fluorophenyl)-2-isopropyl-8-methanesulfonyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate
CAS No.:853181-27-8
Molecular Formula:C₂₀H₂₃FN₂O₄S
Molecular Weight:406.478
Hs Code.:

Synonyms:methyl 4-(4-fluorophenyl)-2-isopropyl-8-methanesulfonyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate

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Chemical Property of methyl 4-(4-fluorophenyl)-2-isopropyl-8-methanesulfonyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate

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Technology Process of methyl 4-(4-fluorophenyl)-2-isopropyl-8-methanesulfonyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate

There total 5 articles about methyl 4-(4-fluorophenyl)-2-isopropyl-8-methanesulfonyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 853181-29-0
methyl 4-(4-fluorophenyl)-2-isopropyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate

: 7143-01-3
Methanesulfonic anhydride

: 853181-27-8
methyl 4-(4-fluorophenyl)-2-isopropyl-8-methanesulfonyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate

Guidance literature:: With 3,5-Lutidine; In dichloromethane; toluene; at 20 ℃; for 72h; Product distribution / selectivity;

Reference yield: 81.0%

: 853181-29-0
methyl 4-(4-fluorophenyl)-2-isopropyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate

: 124-63-0
methanesulfonyl chloride

: 853181-27-8
methyl 4-(4-fluorophenyl)-2-isopropyl-8-methanesulfonyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at -78 ℃; for 1.33333h; Product distribution / selectivity;

Reference yield: 30.0%

: 853181-28-9
methyl 4-(4-fluorophenyl)-2-isopropyl-1,4,4a,5,6,7-hexahydro-[1,8]naphthyridine-3-carboxylate

: 124-63-0
methanesulfonyl chloride

: 7087-68-5
N-ethyl-N,N-diisopropylamine

: 853181-27-8
methyl 4-(4-fluorophenyl)-2-isopropyl-8-methanesulfonyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate

: 36340-89-3
N,N-diisopropylethylamine hydrochloride

Guidance literature:: methyl 4-(4-fluorophenyl)-2-isopropyl-1,4,4a,5,6,7-hexahydro-[1,8]naphthyridine-3-carboxylate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In ethyl acetate; at 0 ℃; for 0.5h;

With ammonium cerium(IV) nitrate; In water; ethyl acetate; at 0 ℃; for 0.333333 - 0.5h;