5-bromo-2-methylphenylguanidine nitrate

Base Information

• Chemical Name: 5-bromo-2-methylphenylguanidine nitrate
• CAS No.: 1206604-19-4
• Molecular Formula: C₈H₁₀BrN₃*HNO₃
• Molecular Weight: 291.104
• Mol file: 1206604-19-4.mol

Synonyms:5-bromo-2-methylphenylguanidine nitrate

Chemical Property of 5-bromo-2-methylphenylguanidine nitrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-2-methylphenylguanidine nitrate

There total 2 articles about 5-bromo-2-methylphenylguanidine nitrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5-bromo-2-methyl aniline hydrochloride + CYANAMID (420-04-2) → 5-bromo-2-methylphenylguanidine nitrate (1206604-19-4)

Guidance literature:

5-bromo-2-methyl aniline hydrochloride; CYANAMID; In tert-butyl alcohol; at 85 ℃; for 4h; Reflux;

With sodium hydroxide; In tert-butyl methyl ether; water; at 25 ℃; for 1h;

With nitric acid; at 12 ℃;

Reference yield: 79.9%

CYANAMID (420-04-2) + 5-bromo-2-methylaniline (39478-78-9) → 5-bromo-2-methylphenylguanidine nitrate (1206604-19-4)

Guidance literature:

5-bromo-2-methylaniline; With nitric acid; In methanol; at 60 ℃; for 0.5h;

CYANAMID; In methanol; water; for 6h; Reflux;

DOI:10.1021/acs.oprd.9b00227

Reference yield: 82.0%

5-bromo-2-methylphenylguanidine nitrate (1206604-19-4) + 3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one (55314-16-4,75415-01-9,123367-26-0) → N-5-bromo-2-methylphenyl(4-pyridine-3-yl)pyrimidine-2-amine (1206604-20-7)

Guidance literature:

With sodium hydrogencarbonate; In butan-1-ol; at 120 ℃; for 16h; Reflux; Inert atmosphere;

upstream raw materials:

CYANAMID

5-bromo-2-methylaniline

Downstream raw materials:

N-5-bromo-2-methylphenyl(4-pyridine-3-yl)pyrimidine-2-amine