tert-butyl 3-(5-(tert-butoxycarbonyl(methyl)amino)-4-cyano-3-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

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Chemical Name:tert-butyl 3-(5-(tert-butoxycarbonyl(methyl)amino)-4-cyano-3-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
CAS No.:1612777-08-8
Molecular Formula:C₃₂H₃₉N₅O₅
Molecular Weight:573.692
Hs Code.:

Synonyms:tert-butyl 3-(5-(tert-butoxycarbonyl(methyl)amino)-4-cyano-3-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 3-(5-(tert-butoxycarbonyl(methyl)amino)-4-cyano-3-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

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Technology Process of tert-butyl 3-(5-(tert-butoxycarbonyl(methyl)amino)-4-cyano-3-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

There total 12 articles about tert-butyl 3-(5-(tert-butoxycarbonyl(methyl)amino)-4-cyano-3-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1612774-48-7
tert-butyl 3-(5-(tert-butoxycarbonylamino)-4-cyano-3-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

: 74-88-4
methyl iodide

: 1612777-08-8
tert-butyl 3-(5-(tert-butoxycarbonyl(methyl)amino)-4-cyano-3-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: tert-butyl 3-(5-(tert-butoxycarbonylamino)-4-cyano-3-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.333333h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 - 60 ℃; for 1h;

Reference yield:

: 330792-69-3
2-[(4-phenoxy-phenyl)-methoxy-methylene]-malononitrile

: 1612777-08-8
tert-butyl 3-(5-(tert-butoxycarbonyl(methyl)amino)-4-cyano-3-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / ethanol / 2 h / 20 - 90 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 50 h / 20 - 80 °C

3.1: dmap; triethylamine / tetrahydrofuran / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 - 20 °C

4.2: 1 h / 20 - 60 °C

With dmap; hydrazine hydrate; sodium hydride; caesium carbonate; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 85275-45-2
N-tert-butoxycarbonyl-3-piperidinol

: 1612777-08-8
tert-butyl 3-(5-(tert-butoxycarbonyl(methyl)amino)-4-cyano-3-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; triethylamine / dichloromethane / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 50 h / 20 - 80 °C

3.1: dmap; triethylamine / tetrahydrofuran / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 - 20 °C

4.2: 1 h / 20 - 60 °C

With dmap; sodium hydride; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;