N-((1S,2S,5R)-5-hydroxy-2-methyl-1,7-diphenylheptyl)-2-nitrobenzenesulfonamide

Base Information

Chemical Name:N-((1S,2S,5R)-5-hydroxy-2-methyl-1,7-diphenylheptyl)-2-nitrobenzenesulfonamide
CAS No.:944454-22-2
Molecular Formula:C₂₆H₃₀N₂O₅S
Molecular Weight:482.601
Hs Code.:

Synonyms:N-((1S,2S,5R)-5-hydroxy-2-methyl-1,7-diphenylheptyl)-2-nitrobenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((1S,2S,5R)-5-hydroxy-2-methyl-1,7-diphenylheptyl)-2-nitrobenzenesulfonamide

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Technology Process of N-((1S,2S,5R)-5-hydroxy-2-methyl-1,7-diphenylheptyl)-2-nitrobenzenesulfonamide

There total 5 articles about N-((1S,2S,5R)-5-hydroxy-2-methyl-1,7-diphenylheptyl)-2-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 944454-19-7
(3R,6S,7S)-7-amino-6-methyl-1,7-diphenylheptan-3-ol

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 944454-22-2
N-((1S,2S,5R)-5-hydroxy-2-methyl-1,7-diphenylheptyl)-2-nitrobenzenesulfonamide

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 2.25h;
DOI:10.1021/ja071974v

Reference yield:

: C₁₃H₁₇O^(1-)*Li⁽¹⁺⁾

: 944454-22-2
N-((1S,2S,5R)-5-hydroxy-2-methyl-1,7-diphenylheptyl)-2-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: Ti(Oi-Pr)4; c-C₅H₉MgCl / diethyl ether / 2.5 h / -60 - -30 °C

1.2: diethyl ether; hexane / 6.5 h / -30 - 20 °C

2.1: 86 percent / H₂; AcOH / Pd(OH)2 / methanol; H₂O / 6 h / 20 °C / 760.05 Torr

3.1: 91 percent / Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2.25 h / 0 - 20 °C

With titanium(IV) isopropylate; dmap; hydrogen; cyclopentylmagnesium chloride; acetic acid; triethylamine; palladium dihydroxide; In methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/ja071974v

Reference yield:

: 944454-17-5
(3R,6S,7S)-7-((R)-2-methoxy-1-phenylethylamino)-6-methyl-1,7-diphenylheptan-3-ol

: 944454-22-2
N-((1S,2S,5R)-5-hydroxy-2-methyl-1,7-diphenylheptyl)-2-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / H₂; AcOH / Pd(OH)2 / methanol; H₂O / 6 h / 20 °C / 760.05 Torr

2: 91 percent / Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2.25 h / 0 - 20 °C

With dmap; hydrogen; acetic acid; triethylamine; palladium dihydroxide; In methanol; dichloromethane; water;
DOI:10.1021/ja071974v