2-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-5-methoxybenzoic acid

Base Information

Chemical Name:2-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-5-methoxybenzoic acid
CAS No.:1445778-97-1
Molecular Formula:C₂₁H₂₈ClN₃O₄
Molecular Weight:421.924
Hs Code.:

Synonyms:2-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-5-methoxybenzoic acid

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Chemical Property of 2-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-5-methoxybenzoic acid

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Technology Process of 2-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-5-methoxybenzoic acid

There total 4 articles about 2-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-5-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1445778-96-0
4-chloro-1-(2-cyano-4-methoxyphenyl)-5-methyl-1H-pyrazole-3-carboxylic acid dibutylamide

: 1445778-97-1
2-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-5-methoxybenzoic acid

Guidance literature:: With water; potassium hydroxide; In ethanol; at 150 ℃; for 1.5h; Microwave irradiation;

Reference yield:

: 4027-57-0
ethyl 5-methyl-1H-pyrazole-3-carboxylate

: 1445778-97-1
2-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-5-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 24 h / 20 °C

2.1: trimethylaluminum / dichloromethane; toluene / 0.5 h / 20 °C / Inert atmosphere

2.2: 12 h / Inert atmosphere

3.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 130 °C / Microwave irradiation

4.1: potassium hydroxide; water / ethanol / 1.5 h / 150 °C / Microwave irradiation

With N-chloro-succinimide; water; trimethylaluminum; caesium carbonate; potassium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 637022-63-0
4-chloro-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 1445778-97-1
2-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-5-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: trimethylaluminum / dichloromethane; toluene / 0.5 h / 20 °C / Inert atmosphere

1.2: 12 h / Inert atmosphere

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 130 °C / Microwave irradiation

3.1: potassium hydroxide; water / ethanol / 1.5 h / 150 °C / Microwave irradiation

With water; trimethylaluminum; caesium carbonate; potassium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;