Technology Process of (S,E)-tert-butyl(dodec-4-en-1-yn-3-yloxy)diphenylsilane
There total 8 articles about (S,E)-tert-butyl(dodec-4-en-1-yn-3-yloxy)diphenylsilane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
carbon tetrabromide;
With
triphenylphosphine; zinc;
In
dichloromethane;
at 0 - 20 ℃;
for 0.5h;
Inert atmosphere;
C27H38O2Si;
In
dichloromethane;
at 0 ℃;
for 1h;
Further stages;
Inert atmosphere;
DOI:10.1016/j.tet.2011.10.058
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / acetone; tert-butyl alcohol / 8 h / 20 °C / Inert atmosphere
1.2: 1 h / 20 °C / Inert atmosphere
2.1: SiO2-supported NaIO4 / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / 0 °C / Inert atmosphere
3.2: 0.5 h / 0 - 20 °C / Inert atmosphere
4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 1 h / 0 - 20 °C / Inert atmosphere
5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C / Inert atmosphere
5.2: 0.75 h / -78 - 20 °C / Inert atmosphere
6.1: triphenylphosphine; zinc / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere
6.2: 1 h / 0 °C / Inert atmosphere
With
osmium(VIII) oxide; n-butyllithium; oxalyl dichloride; SiO2-supported NaIO4; water; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc;
In
tetrahydrofuran; hexane; dichloromethane; water; acetone; tert-butyl alcohol;
1.1: Upjohn dihydroxylation / 3.2: Wittig reaction / 5.1: Swern oxidation / 5.2: Swern oxidation;
DOI:10.1016/j.tet.2011.10.058
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / 0 °C / Inert atmosphere
1.2: 0.5 h / 0 - 20 °C / Inert atmosphere
2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 1 h / 0 - 20 °C / Inert atmosphere
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C / Inert atmosphere
3.2: 0.75 h / -78 - 20 °C / Inert atmosphere
4.1: triphenylphosphine; zinc / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere
4.2: 1 h / 0 °C / Inert atmosphere
With
n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc;
In
tetrahydrofuran; hexane; dichloromethane; water;
1.2: Wittig reaction / 3.1: Swern oxidation / 3.2: Swern oxidation;
DOI:10.1016/j.tet.2011.10.058
