{1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-nitro-benzyl ester

Base Information

• Chemical Name: {1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-nitro-benzyl ester
• CAS No.: 1053267-56-3
• Molecular Formula: C₄₆H₄₃N₅O₁₄
• Molecular Weight: 889.873
• Mol file: 1053267-56-3.mol

Synonyms:{1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-nitro-benzyl ester

Chemical Property of {1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-nitro-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-nitro-benzyl ester

There total 5 articles about {1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

o-nitrobenzyl chloroformate (42854-99-9) + 4-Amino-1-[(2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one (149622-84-4) → {1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-nitro-benzyl ester (1053267-56-3)

Guidance literature:

With water; sodium carbonate; In 1,2-dichloro-ethane; at 25 ℃; for 1h;

DOI:10.1055/s-1999-3098

Reference yield:

2-Nitrobenzyl alcohol (612-25-9) → {1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-nitro-benzyl ester (1053267-56-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent Spectr_. / tetrahydrofuran; toluene / 1.) 4 deg C, 30 min, 2.) 25 deg C, 2.5 h

2: 85 percent / Na₂CO₃, H₂O / 1,2-dichloro-ethane / 1 h / 25 °C

With water; sodium carbonate; In tetrahydrofuran; 1,2-dichloro-ethane; toluene;

DOI:10.1055/s-1999-3098

Reference yield:

N4-acetyl-5'-O-(4,4'-dimethoxytrityl)cytidine (121058-82-0) → {1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-nitro-benzyl ester (1053267-56-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) Bu₂SnCl₂, iPr₂NEt / 1.) (ClCH₂)2, 25 deg C, 60 min, 2.) 70 deg C, 30 min

2: MeNH₂ / ethanol / 0.5 h / 25 °C

3: 85 percent / Na₂CO₃, H₂O / 1,2-dichloro-ethane / 1 h / 25 °C

With dibutyltin chloride; water; sodium carbonate; N-ethyl-N,N-diisopropylamine; methylamine; In ethanol; 1,2-dichloro-ethane;

DOI:10.1055/s-1999-3098

upstream raw materials:

o-nitrobenzyl chloroformate

4-Amino-1-[(2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one

2-Nitrobenzyl alcohol

N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)cytidine