Technology Process of benzyl 2-(5-cyclohexyl-2,4-dioxo-3-(pyridin-2-ylmethyl)-2,3,4,5-tetrahydro-1H-benzo[f][1,3,5]triazepin-1-yl)acetate
There total 5 articles about benzyl 2-(5-cyclohexyl-2,4-dioxo-3-(pyridin-2-ylmethyl)-2,3,4,5-tetrahydro-1H-benzo[f][1,3,5]triazepin-1-yl)acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 65 °C
2.1: 2,4-dichlorophenoxyacetic acid dimethylamine / 0.5 h / 150 °C / Microwave irradiation
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C
3.2: 16 h
With
sodium hydride; potassium carbonate;
In
2,4-dichlorophenoxyacetic acid dimethylamine; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tetlet.2012.05.025
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 2,4-dichlorophenoxyacetic acid dimethylamine / 0.5 h / 150 °C / Microwave irradiation
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C
2.2: 16 h
With
sodium hydride;
In
2,4-dichlorophenoxyacetic acid dimethylamine; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tetlet.2012.05.025
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 0.25 h / 170 °C / Microwave irradiation; Neat (no solvent)
2.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 65 °C
4.1: 2,4-dichlorophenoxyacetic acid dimethylamine / 0.5 h / 150 °C / Microwave irradiation
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C
5.2: 16 h
With
palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate;
In
ethanol; 2,4-dichlorophenoxyacetic acid dimethylamine; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tetlet.2012.05.025