2-(3-Methoxyphenyl)-5,6-dihydroimidazo(2,1-a)isoquinoline

Base Information

Chemical Name:2-(3-Methoxyphenyl)-5,6-dihydroimidazo(2,1-a)isoquinoline
CAS No.:61001-21-6
Molecular Formula:C18H16N2O
Molecular Weight:276.36
Hs Code.:
UNII:ZGC8AS3HYJ
Nikkaji Number:J61.452A

Synonyms:ZGC8AS3HYJ;2-(3-Methoxyphenyl)-5,6-dihydroimidazo(2,1-a)isoquinoline;NIOSH/NI3016000;61001-21-6;NI30160000;2-(m-Methoxyphenyl)-5,6-dihydroimidazo(2,1-a)isoquinoline;5,6-Dihydro-2-(3-methoxyphenyl)imidazo(2,1-a)isoquinoline;Imidazo(2,1-a)isoquinoline, 5,6-dihydro-2-(3-methoxyphenyl)-;Imidazo(2,1-a)isoquinoline, 5,6-dihydro-2-(m-methoxyphenyl)-;UNII-ZGC8AS3HYJ

Suppliers and Price of 2-(3-Methoxyphenyl)-5,6-dihydroimidazo(2,1-a)isoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-(3-Methoxyphenyl)-5,6-dihydroimidazo(2,1-a)isoquinoline

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:276.126263138
Heavy Atom Count:21
Complexity:361

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s): A reproductive hazard.
Hazard Codes:A reproductive hazard.

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=CC(=C1)C2=CN3CCC4=CC=CC=C4C3=N2

Technology Process of 2-(3-Methoxyphenyl)-5,6-dihydroimidazo(2,1-a)isoquinoline

There total 5 articles about 2-(3-Methoxyphenyl)-5,6-dihydroimidazo(2,1-a)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 896868-57-8
1-(3-methoxyphenyl)ethanone O-acetyl oxime

: 61001-21-6
2-(3-methoxyphenyl)-5,6-dihydroimidazo[2,1-a]isoquinoline

Guidance literature:: With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper(l) chloride; In acetonitrile; at 90 ℃; for 12h; regioselective reaction; Molecular sieve;
DOI:10.1021/acs.orglett.9b02978

Reference yield:

: 1532-84-9
isoquinolin-1-ylamine

: 61001-21-6
2-(3-methoxyphenyl)-5,6-dihydroimidazo[2,1-a]isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / 1.) 15 min., room temp., CHCl₃, 2.) 15 min., heating on a steam bath

2: 84 percent / H₂ / 10percent Pd/C / ethanol; acetic acid / 3 h / 90 °C / 7500.6 Torr

With hydrogen; palladium on activated charcoal; In ethanol; acetic acid;

Reference yield:

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 61001-21-6
2-(3-methoxyphenyl)-5,6-dihydroimidazo[2,1-a]isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / 1.) 15 min., room temp., CHCl₃, 2.) 15 min., heating on a steam bath

2: 84 percent / H₂ / 10percent Pd/C / ethanol; acetic acid / 3 h / 90 °C / 7500.6 Torr

With hydrogen; palladium on activated charcoal; In ethanol; acetic acid;