[3-(benzoxazol-6-yloxy)-propyl]-(7-benzyloxy-chroman-2-ylmethyl)amine

Base Information

• Chemical Name: [3-(benzoxazol-6-yloxy)-propyl]-(7-benzyloxy-chroman-2-ylmethyl)amine
• CAS No.: 180716-26-1
• Molecular Formula: C₂₇H₂₈N₂O₄
• Molecular Weight: 444.53
• Mol file: 180716-26-1.mol

Synonyms:[3-(benzoxazol-6-yloxy)-propyl]-(7-benzyloxy-chroman-2-ylmethyl)amine

Chemical Property of [3-(benzoxazol-6-yloxy)-propyl]-(7-benzyloxy-chroman-2-ylmethyl)amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-(benzoxazol-6-yloxy)-propyl]-(7-benzyloxy-chroman-2-ylmethyl)amine

There total 4 articles about [3-(benzoxazol-6-yloxy)-propyl]-(7-benzyloxy-chroman-2-ylmethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-hydroxybenzoxazole (106050-81-1) + 3-{[(2S)-7-benzyloxy-chroman-2-ylmethyl]-amino}-propan-1-ol (180716-20-5) → [3-(benzoxazol-6-yloxy)-propyl]-(7-benzyloxy-chroman-2-ylmethyl)amine (180716-26-1)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 3h;

DOI:10.1021/jm9703653

Reference yield:

ethyl 7-(Benzyloxy)chroman-2-carboxylate (197388-46-8) → [3-(benzoxazol-6-yloxy)-propyl]-(7-benzyloxy-chroman-2-ylmethyl)amine (180716-26-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / LiBH₄ / tetrahydrofuran / 2 h

2: 60 percent / CBr₄, PPh₃ / CH₂Cl₂ / 12 h / Ambient temperature

3: 98 percent / 2 h / 100 °C

4: 95 percent / PPh₃, DEAD / tetrahydrofuran / 3 h

With lithium borohydride; carbon tetrabromide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm9703653

Reference yield:

2-(bromomethyl)-7-(benzyloxy)chroman (180716-18-1) → [3-(benzoxazol-6-yloxy)-propyl]-(7-benzyloxy-chroman-2-ylmethyl)amine (180716-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / 2 h / 100 °C

2: 95 percent / PPh₃, DEAD / tetrahydrofuran / 3 h

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

DOI:10.1021/jm9703653

upstream raw materials:

6-hydroxybenzoxazole

3-{[(2S)-7-benzyloxy-chroman-2-ylmethyl]-amino}-propan-1-ol

ethyl 7-(Benzyloxy)chroman-2-carboxylate

2-(bromomethyl)-7-(benzyloxy)chroman