3-{[(2S)-7-benzyloxy-chroman-2-ylmethyl]-amino}-propan-1-ol

Base Information

• Chemical Name: 3-{[(2S)-7-benzyloxy-chroman-2-ylmethyl]-amino}-propan-1-ol
• CAS No.: 180716-20-5
• Molecular Formula: C₂₀H₂₅NO₃
• Molecular Weight: 327.423
• Mol file: 180716-20-5.mol

Synonyms:3-{[(2S)-7-benzyloxy-chroman-2-ylmethyl]-amino}-propan-1-ol

Chemical Property of 3-{[(2S)-7-benzyloxy-chroman-2-ylmethyl]-amino}-propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{[(2S)-7-benzyloxy-chroman-2-ylmethyl]-amino}-propan-1-ol

There total 3 articles about 3-{[(2S)-7-benzyloxy-chroman-2-ylmethyl]-amino}-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

propan-1-ol-3-amine (156-87-6) + 2-(bromomethyl)-7-(benzyloxy)chroman (180716-18-1) → 3-{[(2S)-7-benzyloxy-chroman-2-ylmethyl]-amino}-propan-1-ol (180716-20-5)

Guidance literature:

at 100 ℃; for 2h;

DOI:10.1021/jm9703653

Reference yield:

ethyl 7-(Benzyloxy)chroman-2-carboxylate (197388-46-8) → 3-{[(2S)-7-benzyloxy-chroman-2-ylmethyl]-amino}-propan-1-ol (180716-20-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / LiBH₄ / tetrahydrofuran / 2 h

2: 60 percent / CBr₄, PPh₃ / CH₂Cl₂ / 12 h / Ambient temperature

3: 98 percent / 2 h / 100 °C

With lithium borohydride; carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm9703653

Reference yield:

3,4-dihydro-7-(phenylmethoxy)-2H-1-benzopyran-2-methanol (180716-16-9) → 3-{[(2S)-7-benzyloxy-chroman-2-ylmethyl]-amino}-propan-1-ol (180716-20-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / CBr₄, PPh₃ / CH₂Cl₂ / 12 h / Ambient temperature

2: 98 percent / 2 h / 100 °C

With carbon tetrabromide; triphenylphosphine; In dichloromethane;

DOI:10.1021/jm9703653

upstream raw materials:

propan-1-ol-3-amine

2-(bromomethyl)-7-(benzyloxy)chroman

ethyl 7-(Benzyloxy)chroman-2-carboxylate

3,4-dihydro-7-(phenylmethoxy)-2H-1-benzopyran-2-methanol

Downstream raw materials:

[3-(benzoxazol-6-yloxy)-propyl]-(7-benzyloxy-chroman-2-ylmethyl)amine

[3-(Benzooxazol-5-yloxy)-propyl]-(7-benzyloxy-chroman-2-ylmethyl)-amine

3-{[(7-benzyloxy)chroman-2-ylmethyl]methylamino}propan-1-ol Fumaric Acid Salt

4-{3-[(7-Benzyloxy-chroman-2-ylmethyl)-amino]-propoxy}-pyrimidin-2-ylamine