Technology Process of C22H18Cl2O2Si
There total 11 articles about C22H18Cl2O2Si which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-methylphenyl bromide;
With
sec.-butyllithium;
In
tetrahydrofuran;
at -78 ℃;
for 0.333333h;
Inert atmosphere;
4,5-dichloro-10,10-dimethyl-10-sila-3,6-bis((tert-butyldimethylsilyl)oxy)-9H-xanthen-9-one;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 1h;
Inert atmosphere;
With
hydrogenchloride;
In
tetrahydrofuran; water;
for 0.333333h;
Inert atmosphere;
- Guidance literature:
-
With
hydrogenchloride; water;
In
tetrahydrofuran;
at 20 ℃;
for 0.333333h;
DOI:10.1002/anie.201210279
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: potassium carbonate / acetonitrile / 80 °C
2.1: acetic acid / 80 °C
3.1: sec.-butyllithium / tetrahydrofuran / -78 °C
3.2: -78 - 20 °C
3.3: 20 °C
4.1: tetrakis(triphenylphosphine) palladium(0); 1,3-dimethylbarbituric acid / dichloromethane / 20 °C
5.1: water; sodium nitrite; sulfuric acid / methanol / 0 °C
5.2: Reflux
6.1: sodium hypochlorite; sodium hydroxide / water; methanol / 1 h / 20 °C
7.1: 1H-imidazole / dichloromethane / 20 °C
8.1: sec.-butyllithium / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere
8.2: 1 h / -78 - 20 °C / Inert atmosphere
9.1: hydrogenchloride; water / tetrahydrofuran / 0.33 h / 20 °C
With
1H-imidazole; hydrogenchloride; sodium hypochlorite; tetrakis(triphenylphosphine) palladium(0); 1,3-dimethylbarbituric acid; sulfuric acid; water; sec.-butyllithium; potassium carbonate; sodium hydroxide; sodium nitrite;
In
tetrahydrofuran; methanol; dichloromethane; water; acetic acid; acetonitrile;
DOI:10.1002/anie.201210279
