3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-pentan-1-ol

Base Information

• Chemical Name: 3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-pentan-1-ol
• CAS No.: 472979-90-1
• Molecular Formula: C₂₁H₃₈O₄Si
• Molecular Weight: 382.616
• Mol file: 472979-90-1.mol

Synonyms:3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-pentan-1-ol

Chemical Property of 3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-pentan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-pentan-1-ol

There total 5 articles about 3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-pentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-pentanoic acid methyl ester (472979-84-3) → 3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-pentan-1-ol (472979-90-1)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 ℃;

DOI:10.1021/ol026468j

Reference yield: 92.0%

C31H45NO6Si (1416328-61-4) → 3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-pentan-1-ol (472979-90-1)

Guidance literature:

With lithium borohydride; In diethyl ether; water; at 0 - 23 ℃; for 3.5h; Inert atmosphere;

DOI:10.1021/ol303089w

Reference yield:

3-(p-methoxybenzyloxy)propanal (128461-65-4) → 3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-pentan-1-ol (472979-90-1)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Tos-D-valine; BH₃*THF; K₂CO₃ / CH₂Cl₂; methanol

2: 99 percent / 2,6-lutidine; DMAP / CH₂Cl₂ / 20 °C

3: 94 percent / DIBAH / toluene / -78 °C

With 2,6-dimethylpyridine; dmap; borane-THF; N-((4-methylphenyl)sulfonyl)-D-valine; diisobutylaluminium hydride; potassium carbonate; In methanol; dichloromethane; toluene;

DOI:10.1021/ol026468j

upstream raw materials:

3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-pentanoic acid methyl ester

3-(p-methoxybenzyloxy)propanal

(S)-3-hydroxy-5-(4-methoxybenzyloxy)-2,2-dimethylpentanoic acid methyl ester

C₃₁H₄₅NO₆Si

Downstream raw materials:

(3S)-3-tert-butyldimethylsilyloxy-5-p-methoxybenzyloxy-2,2-dimethylpentanal

C₃₄H₅₁NO₇Si

C₃₇H₅₉NO₇Si₂

C₂₇H₅₂O₅Si₂