472979-84-3

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 472979-31-0 (S)-3-hydroxy-5-(4-methoxybenzyloxy)-2,2-dimethylpentanoic acid methyl ester 
• 31469-15-5 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene 
• 128461-65-4 3-(p-methoxybenzyloxy)propanal 

Downstream Products

• 472979-51-4 1-[3-(tert-butyl-dimethyl-silanyloxy)-4,4-dimethyl-5-(2-trimethylsilanyl-ethoxymethoxy)-oct-6-enyloxymethyl]-4-methoxy-benzene 
• 472979-46-7 6-(tert-butyl-dimethyl-silanyloxy)-8-(4-methoxy-benzyloxy)-5,5-dimethyl-oct-2-en-4-ol 
• 472979-36-5 (3S)-3-tert-butyldimethylsilyloxy-5-p-methoxybenzyloxy-2,2-dimethylpentanal 
• 472979-90-1 3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-pentan-1-ol 

Relevant academic research and scientific papers

Self-Assembly of Disorazole C1 through a One-Pot Alkyne Metathesis Homodimerization Strategy

Abstract Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne-metathesis-based homodimerization approach to natural products. In this approach to the cytotoxic C2-symmetric marine-derived bis(lactone) disorazole C1, a highly convergent, modular strategy is employed featuring cyclization through an ambitious one-pot alkyne cross-metathesis/ring-closing metathesis self-assembly process.

Toward the total synthesis of disorazole A(1) and C(1): asymmetric synthesis of a masked southern segment.

[reaction: see text] A highly convergent asymmetric synthesis of the masked southern segment of the antimitotic agent disorazole A(1) involves a Sonogashira coupling between a C1'-C10' enyne and a suitably protected C11'-C19' vinyl iodide. The central E,Z,Z-triene moiety is masked as a more stable ynediene.