N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanyl-glycyl methyl ester

Base Information

Chemical Name:N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanyl-glycyl methyl ester
CAS No.:140647-66-1
Molecular Formula:C₂₇H₂₄F₂N₂O₅
Molecular Weight:494.495
Hs Code.:

Synonyms:N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanyl-glycyl methyl ester

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Chemical Property of N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanyl-glycyl methyl ester

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Technology Process of N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanyl-glycyl methyl ester

There total 2 articles about N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanyl-glycyl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 140647-56-9
N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanine

: 616-34-2
methoxycarbonylmethylamine

: 140647-66-1
N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanyl-glycyl methyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1016/S0022-1139(00)81249-X

Reference yield:

: 140647-78-5
N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanyl methyl ester

: 140647-66-1
N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanyl-glycyl methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / aq. 6M HCl / dioxane; H₂O / 5 h / Heating

2: 80 percent / N-methylmorpholine, hydoxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0022-1139(00)81249-X