N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanyl methyl ester

Base Information

Chemical Name:N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanyl methyl ester
CAS No.:140647-78-5
Molecular Formula:C₂₅H₂₁F₂NO₄
Molecular Weight:437.443
Hs Code.:

Synonyms:N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanyl methyl ester

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Chemical Property of N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanyl methyl ester

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Technology Process of N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanyl methyl ester

There total 1 articles about N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanyl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 73757-44-5
Methyl 3,3-difluoro-2-amino-3-phenylpropionate

: 140647-78-5
N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanyl methyl ester

Guidance literature:: With 4-methyl-morpholine; In 1,4-dioxane; Ambient temperature;
DOI:10.1016/S0022-1139(00)81249-X

Reference yield: 67.0%

: 140647-78-5
N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanyl methyl ester

: 140647-56-9
N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; for 5h; Heating;
DOI:10.1016/S0022-1139(00)81249-X

Reference yield:

: 140647-78-5
N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanyl methyl ester

: 140647-66-1
N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanyl-glycyl methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / aq. 6M HCl / dioxane; H₂O / 5 h / Heating

2: 80 percent / N-methylmorpholine, hydoxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0022-1139(00)81249-X