5'-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-2-fluoro-2'-methylbiphenyl-4-carboxamide

Base Information

Chemical Name:5'-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-2-fluoro-2'-methylbiphenyl-4-carboxamide
CAS No.:945244-57-5
Molecular Formula:C₂₅H₂₁FN₂O₄
Molecular Weight:432.451
Hs Code.:

Synonyms:5'-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-2-fluoro-2'-methylbiphenyl-4-carboxamide

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Chemical Property of 5'-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-2-fluoro-2'-methylbiphenyl-4-carboxamide

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Technology Process of 5'-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-2-fluoro-2'-methylbiphenyl-4-carboxamide

There total 6 articles about 5'-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-2-fluoro-2'-methylbiphenyl-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 759427-20-8
4-bromo-3-fluorobenzamide

: 945244-23-5
1-(benzo[d][1,3]dioxol-5-yl)-N-(4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxamide

: 945244-57-5
5'-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-2-fluoro-2'-methylbiphenyl-4-carboxamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

Reference yield:

: 945244-49-5
1-(benzo[d][1,3]dioxol-5-yl)-N-(3-bromo-4-methylphenyl)cyclopropanecarboxamide

: 945244-57-5
5'-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-2-fluoro-2'-methylbiphenyl-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / Pd(dppf)Cl₂ / dichloromethane; N,N-dimethyl-formamide

2: K₂CO₃ / N,N-dimethyl-formamide

With K₂CO₃; potassium acetate; Pd(dppf)Cl₂; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 4439-02-5
3,4-methylenedioxyphenylacetonitrile

: 945244-57-5
5'-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-2-fluoro-2'-methylbiphenyl-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; sodium hydroxide; sodium chloride; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane

2: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / methanol; ethyl acetate; N,N-dimethyl-formamide

3: K₂CO₃ / N,N-dimethyl-formamide

With hydrogenchloride; sodium hydroxide; K₂CO₃; sodium chloride; N-benzyl-N,N,N-triethylammonium chloride; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;