methyl 3,4-anhydro-2-O-mesyl-6-O-trityl-α-D-altropyranoside

Base Information

• Chemical Name: methyl 3,4-anhydro-2-O-mesyl-6-O-trityl-α-D-altropyranoside
• CAS No.: 118360-80-8
• Molecular Formula: C₂₇H₂₈O₇S
• Molecular Weight: 496.581
• Mol file: 118360-80-8.mol

Synonyms:methyl 3,4-anhydro-2-O-mesyl-6-O-trityl-α-D-altropyranoside

Chemical Property of methyl 3,4-anhydro-2-O-mesyl-6-O-trityl-α-D-altropyranoside

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3,4-anhydro-2-O-mesyl-6-O-trityl-α-D-altropyranoside

There total 5 articles about methyl 3,4-anhydro-2-O-mesyl-6-O-trityl-α-D-altropyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2,3-di-O-mesyl-6-O-trityl-α-D-mannopyranoside (16802-89-4) → methyl 3,4-anhydro-2-O-mesyl-6-O-trityl-α-D-altropyranoside (118360-80-8)

Guidance literature:

With sodium methylate; In 1,4-dioxane; methanol; at 25 ℃; for 14h; Yield given;

DOI:10.1246/bcsj.65.2974

Reference yield:

(2R,3S,4S,5S,6S)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol (617-04-9) → methyl 3,4-anhydro-2-O-mesyl-6-O-trityl-α-D-altropyranoside (118360-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 4-dimethylaminopyridine / 1.) pyridine, room temp., 24 h.; 2.) pyridine, room temp., 8 h.

2: 75.4 g / sodium methoxide / CHCl₃; methanol / 14 h / Ambient temperature

With dmap; sodium methylate; In methanol; chloroform;

DOI:10.1246/bcsj.61.2525

Reference yield:

trityl chloride (76-83-5) → methyl 3,4-anhydro-2-O-mesyl-6-O-trityl-α-D-altropyranoside (118360-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 4-dimethylaminopyridine / 1.) pyridine, room temp., 24 h.; 2.) pyridine, room temp., 8 h.

2: 75.4 g / sodium methoxide / CHCl₃; methanol / 14 h / Ambient temperature

With dmap; sodium methylate; In methanol; chloroform;

DOI:10.1246/bcsj.61.2525

upstream raw materials:

methyl 2,3-di-O-mesyl-6-O-trityl-α-D-mannopyranoside

trityl chloride

(2R,3S,4S,5S,6S)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol

methyl 6-O-trityl-α-D-mannopyranoside

Downstream raw materials:

methyl 4-bromo-2,4-dideoxy-2-C-methyl-6-O-triphenylmethyl-α-D-idopyranoside

(2R,3S,5S,6S)-3-Benzyloxy-6-methoxy-5-methyl-2-trityloxymethyl-tetrahydro-pyran

methyl 3,4-anhydro-2-deoxy-2-C-methyl-6-O-trityl-α-D-altropyranoside

methyl 2,4-dideoxy-2-C-methyl-6-O-(triphenylmethyl)-α-D-arabino-hexopyranoside