2-(3-Benzyloxycarbonylamino-propionylamino)-benzoic acid methyl ester

Base Information

• Chemical Name: 2-(3-Benzyloxycarbonylamino-propionylamino)-benzoic acid methyl ester
• CAS No.: 207978-51-6
• Molecular Formula: C₁₉H₂₀N₂O₅
• Molecular Weight: 356.378
• Mol file: 207978-51-6.mol

Synonyms:2-(3-Benzyloxycarbonylamino-propionylamino)-benzoic acid methyl ester

Chemical Property of 2-(3-Benzyloxycarbonylamino-propionylamino)-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 2-(3-Benzyloxycarbonylamino-propionylamino)-benzoic acid methyl ester

There total 1 articles about 2-(3-Benzyloxycarbonylamino-propionylamino)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(benzyloxycarbonylamino)propanoic acid (2304-94-1) + 2-carbomethoxyaniline (134-20-3) → 2-(3-Benzyloxycarbonylamino-propionylamino)-benzoic acid methyl ester (207978-51-6)

Guidance literature:

With 1,1'-carbonyldiimidazole;

DOI:10.1016/S0960-894X(97)00108-X

Reference yield:

2-(3-Benzyloxycarbonylamino-propionylamino)-benzoic acid methyl ester (207978-51-6) → 2-(2-Amino-ethyl)-3-(3-isopropoxy-phenyl)-3H-quinazolin-4-one (207978-52-7)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. LiOH / dioxane / 24 h

2: 1.) 1,1-carbonyldiimidazole / 1.) THF, RT, 1 h, 2.) THF, reflux, 24 h

3: H₂ / 20percent Pd/C / methanol / 4 h / 30 °C / 760 Torr

With lithium hydroxide; hydrogen; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In 1,4-dioxane; methanol;

DOI:10.1021/jm970373j

Reference yield:

2-(3-Benzyloxycarbonylamino-propionylamino)-benzoic acid methyl ester (207978-51-6) → 1-(4-Bromo-phenyl)-3-{2-[3-(3-isopropoxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-ethyl}-urea

Guidance literature:

Multi-step reaction with 4 steps

1: aq. LiOH / dioxane / 24 h

2: 1.) 1,1-carbonyldiimidazole / 1.) THF, RT, 1 h, 2.) THF, reflux, 24 h

3: H₂ / 20percent Pd/C / methanol / 4 h / 30 °C / 760 Torr

4: ethyl acetate / 2 h / Ambient temperature

With lithium hydroxide; hydrogen; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In 1,4-dioxane; methanol; ethyl acetate;

DOI:10.1021/jm970373j

upstream raw materials:

3-(benzyloxycarbonylamino)propanoic acid

2-carbomethoxyaniline

Downstream raw materials:

2-(3-Benzyloxycarbonylamino-propionylamino)-benzoic acid

2-(2-Amino-ethyl)-3-(3-isopropoxy-phenyl)-3H-quinazolin-4-one

{2-[3-(3-Isopropoxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-ethyl}-carbamic acid benzyl ester