4a,5,9,10,11,12-hexahydro-1-bromo-3-methoxy-11-methyl-6H-12-oxobenzofuro[3a,3,2,-ef][2]-benzazepin-6-one

Base Information

Chemical Name:4a,5,9,10,11,12-hexahydro-1-bromo-3-methoxy-11-methyl-6H-12-oxobenzofuro[3a,3,2,-ef][2]-benzazepin-6-one
CAS No.:261961-56-2
Molecular Formula:C₁₇H₁₆BrNO₄
Molecular Weight:378.222
Hs Code.:

Synonyms:4a,5,9,10,11,12-hexahydro-1-bromo-3-methoxy-11-methyl-6H-12-oxobenzofuro[3a,3,2,-ef][2]-benzazepin-6-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4a,5,9,10,11,12-hexahydro-1-bromo-3-methoxy-11-methyl-6H-12-oxobenzofuro[3a,3,2,-ef][2]-benzazepin-6-one

Chemical Property:

Purity/Quality:: 98% HPLC ^*data from raw suppliers

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Technology Process of 4a,5,9,10,11,12-hexahydro-1-bromo-3-methoxy-11-methyl-6H-12-oxobenzofuro[3a,3,2,-ef][2]-benzazepin-6-one

There total 1 articles about 4a,5,9,10,11,12-hexahydro-1-bromo-3-methoxy-11-methyl-6H-12-oxobenzofuro[3a,3,2,-ef][2]-benzazepin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 24958-44-9
2-bromo-4-methoxy-5-hydroxy-N-[2-(4-hydroxyphenyl)-ethyl]-N-methylbenzamide

: 261961-56-2
4a,5,9,10,11,12-hexahydro-1-bromo-3-methoxy-11-methyl-6H-12-oxobenzofuro[3a,3,2,-ef][2]-benzazepin-6-one

Guidance literature:: With potassium hydrogencarbonate; potassium hexacyanoferrate(III); In Isopropyl acetate; water; Product distribution / selectivity;

Reference yield:

: 261961-56-2
4a,5,9,10,11,12-hexahydro-1-bromo-3-methoxy-11-methyl-6H-12-oxobenzofuro[3a,3,2,-ef][2]-benzazepin-6-one

: 357-70-0,1668-85-5,23173-12-8,23173-13-9,60384-53-4
galanthamine

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / p-TsOH / toluene / 2 h / Heating

2: LiAlH₄ / dioxane / 3 h / Heating

3: 58 mg / conc. HCl / H₂O; dioxane / 0.25 h / 20 °C / pH 1

4: 93 percent / L-selectride / tetrahydrofuran / -78 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; L-Selectride; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; water; toluene; 1: cyclocondensation / 2: Reduction / 3: ketal cleavage / 4: Reduction;
DOI:10.1080/00397910008087434

Reference yield:

: 261961-56-2
4a,5,9,10,11,12-hexahydro-1-bromo-3-methoxy-11-methyl-6H-12-oxobenzofuro[3a,3,2,-ef][2]-benzazepin-6-one

: 296237-49-5,26601-10-5
4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / p-TsOH / toluene / 2 h / Heating

2: LiAlH₄ / dioxane / 3 h / Heating

3: 58 mg / conc. HCl / H₂O; dioxane / 0.25 h / 20 °C / pH 1

With hydrogenchloride; lithium aluminium tetrahydride; toluene-4-sulfonic acid; In 1,4-dioxane; water; toluene; 1: cyclocondensation / 2: Reduction / 3: ketal cleavage;
DOI:10.1080/00397910008087434