7-Chlorothieno[3,2-b]pyridine

Base Information

• Chemical Name: 7-Chlorothieno[3,2-b]pyridine
• CAS No.: 69627-03-8
• Molecular Formula: C7H4ClNS
• Molecular Weight: 169.634
• Hs Code.: 2934999090
• Mol file: 69627-03-8.mol

Synonyms:7-Chlorothieno[3,2-b]pyridine;7-Chlorothieno[3,2-b]pyri...;7-chlorothieno[3

Chemical Property of 7-Chlorothieno[3,2-b]pyridine

Chemical Property:

• Vapor Pressure: 0.0234mmHg at 25°C
• Melting Point: 34.0-35.5 °C
• Refractive Index: 1.695
• Boiling Point: 257.5 °C at 760 mmHg
• PKA: 2.87±0.30(Predicted)
• Flash Point: 109.5 °C
• PSA: 41.13000
• Density: 1.435 g/cm³
• LogP: 2.94970
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98% ^*data from raw suppliers

7-Chlorothieno[3,2-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-Chlorothieno[3,2-b]pyridine

There total 13 articles about 7-Chlorothieno[3,2-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

thieno[3,2-b]pyridin-7-ol (69627-02-7,107818-20-2) → 7-chlorothieno[3,2-b]pyridine (69627-03-8)

Guidance literature:

thieno[3,2-b]pyridin-7-ol; With trichlorophosphate; at 60 - 100 ℃; for 3.5h;

With ammonia; water; at 0 ℃;

Reference yield: 90.0%

thieno[3,2-b]pyridin-7(4H)-one (69627-02-7) → 7-chlorothieno[3,2-b]pyridine (69627-03-8)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; 1,2-dichloro-ethane; for 6h; Reflux;

Reference yield: 78.0%

→ 7-chlorothieno[3,2-b]pyridine (69627-03-8)

Guidance literature:

upstream raw materials:

thieno<3,2-b>pyridine 4-oxide monohydrate

7-chlorothieno<3,2-b>pyridine 4-oxide

thieno[3,2-b]pyridin-7(4H)-one

6-ethoxycarbonylthieno<3,2-b>pyridin-7(4H)-one

Downstream raw materials:

thieno[3,2-b]pyridine

7-chloro-2-iodo-[3,2-b]thienopyridine

1-(7-chlorothieno[3,2-b]pyridin-2-yl)propan-1-one

5,6-Dimethyl-3-(thieno[3,2-b]pyridin-7-yloxy)-[2,2']bipyridine

Refernces

• 1、 -. "NITROGEN-CONTAINING FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF". . . Retrieved 2022/01/03.
• 2、 Fang, Sen-Biao,Li, Hui-Jing,Nan, Xiang,Wu, Rui,Wu, Yan-Chao,Zhang, Jing,Zhang, Zhi-Zhou. "Design, synthesis and biological evaluation of novel N-sulfonylamidine-based derivatives as c-Met inhibitors via Cu-catalyzed three-component reaction". . . Retrieved 2020/06/04.