Thieno[3,2-b]pyridine

Base Information

• Chemical Name: Thieno[3,2-b]pyridine
• CAS No.: 272-67-3
• Molecular Formula: C7H5NS
• Molecular Weight: 135.189
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID70480597
• Nikkaji Number: J1.373.585I
• Wikidata: Q72508399
• Mol file: 272-67-3.mol

Synonyms:thienopyridine

Chemical Property of Thieno[3,2-b]pyridine

Chemical Property:

• Vapor Pressure: 0.073mmHg at 25°C
• Refractive Index: 1.6391 (21℃)
• Boiling Point: 236.472oC at 760 mmHg
• PKA: 4.74±0.30(Predicted)
• Flash Point: 100.205oC
• PSA: 41.13000
• Density: 1.272g/cm3
• LogP: 2.29630
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 135.01427034
• Heavy Atom Count: 9
• Complexity: 105

Purity/Quality:

97% ^*data from raw suppliers

Thieno[3,2-B]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=CS2)N=C1
• Recent ClinicalTrials: GORE? CARDIOFORM Septal Occluder Migraine Clinical Study
• Recent EU Clinical Trials: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Dose-Escalation and Dose-Confirmation Study to Evaluate the Safety and Efficacy of Rivaroxaban in Combination with Aspirin Alone or with Aspirin and a Thienopyridine in Subjects with Acute Coronary Syndromes (39039039ACS2001)

Technology Process of Thieno[3,2-b]pyridine

There total 3 articles about Thieno[3,2-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

7-chlorothieno[3,2-b]pyridine (69627-03-8) → thieno[3,2-b]pyridine (272-67-3)

Guidance literature:

With acetic acid; zinc; for 5h; Ambient temperature;

Reference yield:

thieno[3,2-b]pyridin-7-ol (69627-02-7,107818-20-2) → thieno[3,2-b]pyridine (272-67-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: phosphorus(V) oxybromide / 3 h / 110 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C

2.2: 1 h / 20 °C

With n-butyllithium; phosphorus(V) oxybromide; In tetrahydrofuran; hexane;

Reference yield:

3-[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidenemethyl)amino]thiophene-2-carbaldehyde (1217903-01-9) → thieno[3,2-b]pyridin-7(4H)-one (69627-02-7) + thieno[3,2-b]pyridine (272-67-3)

Guidance literature:

at 120 - 550 ℃; for 0.133333h; under 0.021 Torr; Flash vacuum pyrolysis;

DOI:10.1039/b9nj00474b

upstream raw materials:

7-chlorothieno[3,2-b]pyridine

3-[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidenemethyl)amino]thiophene-2-carbaldehyde

thieno[3,2-b]pyridin-7-ol

Downstream raw materials:

2-hydroxymethylthieno<3,2-b>pyridine

2-bromothieno<3,2-b>pyridine

2,3-dibromothieno<3,2-b>pyridine

2-iodothieno<3,2-b>pyridine

Refernces

A New Version of Multicomponent Synthesis of 4,6-Diaryl-2-sulfanylidene-1,2-dihydropyridine-3-carbonitrile Derivatives

10.1134/S1070428018090014

The research focuses on the development of a new multicomponent synthesis method for the production of 4,6-diaryl-2-sulfanylidene-1,2-dihydropyridine-3-carbonitrile derivatives, which are important heterocyclic compounds with potential applications in the synthesis of antihypertensive and antidiabetic agents. The study involves the condensation of aromatic aldehydes, acetophenones, cyanothioacetamide, and alkylating agents to yield a variety of pyridine and thienopyridine derivatives. The synthesized compounds were confirmed through X-ray analysis, spectral data, and other analytical techniques. The study concludes that this method is advantageous due to the accessibility of initial reactants, simplicity of experimental procedures, high yields, and alignment with environmental safety demands.

Applying an aza-wittig reaction for the synthesis of novel thieno[3′,2′:5,6] pyrido[4,3-d]pyrimidinone derivatives

10.1080/10426500802101109

The study investigates the synthesis of a series of new 2-substituted tetrahydrobenzo[4′,5′]thieno[3,2:5,6]pyrido[4,3-d]pyrimidin-4(3H)-ones using an aza-Wittig reaction. The key chemicals involved include iminophosphoranes (3a and 3b), which are derived from tetrahydrobenzo[4,5]thieno[2,3-b]pyridines (2a and 2b) through a reaction with triphenylphosphine, hexachloroethane, and Et3N. These iminophosphoranes react with 4-Cl-phenyl or 4-F-phenyl isocyanates to form carbodiimides (4a and 4b). In the presence of a catalytic amount of K2CO3, these carbodiimides cyclize with phenols to produce the target compounds (5). The study explores the synthesis process, yields, and structural confirmation of these compounds using techniques such as 1H NMR, EI-MS, IR spectroscopy, and elemental analyses. The research aims to explore the potential biological activities of these novel pyridine derivatives containing the thienopyridine and pyridopyrimidine rings.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 272-67-3 Thieno[3,2-b]pyridine

Send

Send

Metric Ton KG G Pound L ML

Send

Send