N-(3-(5-(3-ethoxy-phenyl)-thiophene-2-yl-carbonyl)-phenyl)-isophthalamic acid

Base Information

Chemical Name:N-(3-(5-(3-ethoxy-phenyl)-thiophene-2-yl-carbonyl)-phenyl)-isophthalamic acid
CAS No.:1617505-92-6
Molecular Formula:C₂₇H₂₁NO₅S
Molecular Weight:471.533
Hs Code.:

Synonyms:N-(3-(5-(3-ethoxy-phenyl)-thiophene-2-yl-carbonyl)-phenyl)-isophthalamic acid

Suppliers and Price of N-(3-(5-(3-ethoxy-phenyl)-thiophene-2-yl-carbonyl)-phenyl)-isophthalamic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(3-(5-(3-ethoxy-phenyl)-thiophene-2-yl-carbonyl)-phenyl)-isophthalamic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-(5-(3-ethoxy-phenyl)-thiophene-2-yl-carbonyl)-phenyl)-isophthalamic acid

There total 4 articles about N-(3-(5-(3-ethoxy-phenyl)-thiophene-2-yl-carbonyl)-phenyl)-isophthalamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1617505-91-5
N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)phenyl)-isophthalamicacid methyl ester

: 1617505-92-6
N-(3-(5-(3-ethoxy-phenyl)-thiophene-2-yl-carbonyl)-phenyl)-isophthalamic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 2h; Reflux;
DOI:10.1016/j.ejmech.2014.05.074

Reference yield:

: 121-90-4
m-nitrobenzoic acid chloride

: 1617505-92-6
N-(3-(5-(3-ethoxy-phenyl)-thiophene-2-yl-carbonyl)-phenyl)-isophthalamic acid

Guidance literature:: Multi-step reaction with 5 steps

1: aluminum (III) chloride / dichloromethane / 0 - 20 °C

2: tin(II) chloride dihdyrate / methanol / 2 h / Reflux

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / Inert atmosphere; Reflux

4: pyridine / Reflux

5: sodium hydroxide / ethanol / 2 h / Reflux

With pyridine; aluminum (III) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; caesium carbonate; sodium hydroxide; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 1: |Friedel-Crafts Acylation / 3: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.05.074

Reference yield:

: 269745-89-3
(5-bromo-thiophen-2-yl)-(3-nitrophenyl)methanone

: 1617505-92-6
N-(3-(5-(3-ethoxy-phenyl)-thiophene-2-yl-carbonyl)-phenyl)-isophthalamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: tin(II) chloride dihdyrate / methanol / 2 h / Reflux

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / Inert atmosphere; Reflux

3: pyridine / Reflux

4: sodium hydroxide / ethanol / 2 h / Reflux

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; caesium carbonate; sodium hydroxide; In methanol; 1,2-dimethoxyethane; ethanol; water; 2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.05.074