N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)phenyl)-isophthalamicacid methyl ester

Base Information

Chemical Name:N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)phenyl)-isophthalamicacid methyl ester
CAS No.:1617505-91-5
Molecular Formula:C₂₈H₂₃NO₅S
Molecular Weight:485.56
Hs Code.:

Synonyms:N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)phenyl)-isophthalamicacid methyl ester

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Chemical Property of N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)phenyl)-isophthalamicacid methyl ester

Chemical Property:

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Technology Process of N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)phenyl)-isophthalamicacid methyl ester

There total 4 articles about N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)phenyl)-isophthalamicacid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1617505-82-4
(3-amino-phenyl)(5-(3-ethoxy-phenyl)-thiophen-2-yl)methanone

: 3441-03-0
3-(methoxycarbonyl)benzoyl chloride

: 1617505-91-5
N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)phenyl)-isophthalamicacid methyl ester

Guidance literature:: With pyridine; Reflux;
DOI:10.1016/j.ejmech.2014.05.074

Reference yield:

: 269745-89-3
(5-bromo-thiophen-2-yl)-(3-nitrophenyl)methanone

: 1617505-91-5
N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)phenyl)-isophthalamicacid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tin(II) chloride dihdyrate / methanol / 2 h / Reflux

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / Inert atmosphere; Reflux

3: pyridine / Reflux

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; caesium carbonate; In methanol; 1,2-dimethoxyethane; water; 2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.05.074

Reference yield:

: 121-90-4
m-nitrobenzoic acid chloride

: 1617505-91-5
N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)phenyl)-isophthalamicacid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: aluminum (III) chloride / dichloromethane / 0 - 20 °C

2: tin(II) chloride dihdyrate / methanol / 2 h / Reflux

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / Inert atmosphere; Reflux

4: pyridine / Reflux

With pyridine; aluminum (III) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; caesium carbonate; In methanol; 1,2-dimethoxyethane; dichloromethane; water; 1: |Friedel-Crafts Acylation / 3: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.05.074