N-Boc-2-(aminomethyl)pyridine

Base Information

• Chemical Name: N-Boc-2-(aminomethyl)pyridine
• CAS No.: 134807-28-6
• Molecular Formula: C11H16N2O2
• Molecular Weight: 208.26
• Hs Code.: 2933399090
• European Community (EC) Number: 627-207-4
• ChEMBL ID: CHEMBL4986347
• DSSTox Substance ID: DTXSID40476942
• Nikkaji Number: J3.143.944B
• Wikidata: Q82308902
• Mol file: 134807-28-6.mol

Synonyms:134807-28-6;N-Boc-2-(aminomethyl)pyridine;N-Boc-2-aminomethylpyridine;TERT-BUTYL N-(PYRIDIN-2-YLMETHYL)CARBAMATE;N-BOC-2-AMINOMETHYLPYRIDINE 97;MFCD07369743;TERT-BUTYL PYRIDIN-2-YLMETHYLCARBAMATE;tert-Butyl (pyridin-2-ylmethyl)carbamate;tert-butyl N-[(pyridin-2-yl)methyl]carbamate;2-[N-(tert-butoxycarbonyl)aminomethyl]pyridine;CARBAMIC ACID, (2-PYRIDINYLMETHYL)-, 1,1-DIMETHYLETHYL ESTER;SCHEMBL4678395;CHEMBL4986347;DTXSID40476942;RKVWMMAKYQABGS-UHFFFAOYSA-N;tert-Butyl 2-pyridylmethylcarbamate;N-Boc-2-aminomethylpyridine, 97%;AR2549;t-butyl (2-pyridinylmethyl)carbamate;AKOS013100159;tert-butyl N-(2-pyridylmethyl)carbamate;tert-Butyl(pyridin-2-ylmethyl)carbamate;AS-64465;SY003873;CS-0171917;FT-0687548;2-(N-(t-Butyloxycarbonyl)aminomethyl)pyridine;EN300-80460;2-(N-(t-butyloxycarbonyl)aminomethyl)-pyridine;J-006605;Carbamic acid,N-(2-pyridinylmethyl)-,1,1-dimethylethyl ester

Chemical Property of N-Boc-2-(aminomethyl)pyridine

Chemical Property:

• Vapor Pressure: 0.000171mmHg at 25°C
• Refractive Index: n20/D 1.5020(lit.)
• Boiling Point: 330 °C at 760 mmHg
• Flash Point: 153.4 °C
• PSA: 51.22000
• Density: 1.074 g/cm³
• LogP: 2.49720
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 208.121177757
• Heavy Atom Count: 15
• Complexity: 211

Purity/Quality:

98% 98%atom%13C ^*data from raw suppliers

N-Boc-2-(aminomethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38-43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NCC1=CC=CC=N1

Technology Process of N-Boc-2-(aminomethyl)pyridine

There total 5 articles about N-Boc-2-(aminomethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(Aminomethyl)pyridine (3731-51-9) + di-tert-butyl dicarbonate (24424-99-5) → 2-[N-(tert-butoxycarbonyl)aminomethyl]pyridine (134807-28-6)

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.carres.2010.10.011

Reference yield: 58.0%

2-pyridyl dimethylsulfamate (1282034-09-6) + potassium tert-butyl N-[(trifluorolambda-4-boranyl)methyl]carbamate (1314538-55-0) → 2-[N-(tert-butoxycarbonyl)aminomethyl]pyridine (134807-28-6)

Guidance literature:

With chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II); potassium carbonate; In water; tert-butyl alcohol; at 85 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ol401021x

Reference yield: 35.0%

2-chloropyridine (109-09-1) + potassium tert-butyl N-[(trifluorolambda-4-boranyl)methyl]carbamate (1314538-55-0) → 2-[N-(tert-butoxycarbonyl)aminomethyl]pyridine (134807-28-6)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate; In water; toluene; at 85 ℃; for 22h; Inert atmosphere;

DOI:10.1021/ol2014768

upstream raw materials:

2-(Aminomethyl)pyridine

di-tert-butyl dicarbonate

2-chloropyridine

potassium tert-butyl N-[(trifluorolambda-4-boranyl)methyl]carbamate

Downstream raw materials:

piperidine-2-yl-methylcarbamic acid tert-butyl ester

N-methyl-2-pyridinemethanamine

N-<carbonyl>valine p-nitrophenyl ester

(2S,3S,4S,5S)-5-amino-2-carbonyl>valinyl>amino>-3,4-dihydroxy-1,6-diphenylhexane