N-(5-(hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide

Base Information

• Chemical Name: N-(5-(hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide
• CAS No.: 1418192-03-6
• Molecular Formula: C₁₂H₁₁FN₄O₂S
• Molecular Weight: 294.309
• Mol file: 1418192-03-6.mol

Synonyms:N-(5-(hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide

Chemical Property of N-(5-(hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-(hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide

There total 3 articles about N-(5-(hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

ethyl 2-(4-fluorobenzamido)-4-methylthiazole-5-carboxylate (330978-60-4) → N-(5-(hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide (1418192-03-6)

Guidance literature:

With hydrazine hydrate; In N,N-dimethyl-formamide; for 0.0166667h; Microwave irradiation; Inert atmosphere; Green chemistry;

DOI:10.1016/j.jfluchem.2012.10.012

Reference yield:

ethyl-2-amino-4-methylthiazole-5-carboxylate (7210-76-6) → N-(5-(hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide (1418192-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 0.03 h / Microwave irradiation; Inert atmosphere; Green chemistry

2: hydrazine hydrate / N,N-dimethyl-formamide / 0.02 h / Microwave irradiation; Inert atmosphere; Green chemistry

With hydrazine hydrate; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1016/j.jfluchem.2012.10.012

Reference yield:

4-fluorobenzoyl chloride (403-43-0) → N-(5-(hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide (1418192-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 0.03 h / Microwave irradiation; Inert atmosphere; Green chemistry

2: hydrazine hydrate / N,N-dimethyl-formamide / 0.02 h / Microwave irradiation; Inert atmosphere; Green chemistry

With hydrazine hydrate; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1016/j.jfluchem.2012.10.012

upstream raw materials:

ethyl-2-amino-4-methylthiazole-5-carboxylate

4-fluorobenzoyl chloride

ethyl 2-(4-fluorobenzamido)-4-methylthiazole-5-carboxylate

Downstream raw materials:

N-(5-(2-(5-benzylidene-4-oxo-3-phenylthiazolidin-2-ylidene)hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide

N-(5-(2-(5-(2-hydroxybenzylidene)-4-oxo-3-phenylthiazolidin-2-ylidene)hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide

N-(5-(2-(5-(3-hydroxybenzylidene)-4-oxo-3-phenylthiazolidin-2-ylidene)hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide

N-(5-(2-(5-(4-hydroxybenzylidene)-4-oxo-3-phenylthiazolidin-2-ylidene)hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide