(S)-2-(1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetic acid

Base Information

Chemical Name:(S)-2-(1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetic acid
CAS No.:1278520-77-6
Molecular Formula:C₃₂H₂₈ClN₃O₅
Molecular Weight:570.044
Hs Code.:

Synonyms:(S)-2-(1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetic acid

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Chemical Property of (S)-2-(1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetic acid

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Technology Process of (S)-2-(1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetic acid

There total 9 articles about (S)-2-(1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1278520-76-5
(S)-N-(3-chloro-4-(3-oxo3,4,6,11,12,12a-hexahydro-1H-benzo[e][1,4]oxazino[4,3-a][1,4]diazepine-11-carbonyl)phenyl)biphenyl-2-carboxamide

: 1278520-77-6
(S)-2-(1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetic acid

Guidance literature:: (S)-N-(3-chloro-4-(3-oxo3,4,6,11,12,12a-hexahydro-1H-benzo[e][1,4]oxazino[4,3-a][1,4]diazepine-11-carbonyl)phenyl)biphenyl-2-carboxamide; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In methanol; dichloromethane; water; pH=7 - 8;

Reference yield:

: 947-84-2
2-Biphenylcarboxylic acid

: 1278520-77-6
(S)-2-(1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 5 - 20 °C

2.1: chloro-trimethyl-silane; pyridine / toluene / 0.5 h / 5 °C

2.2: 2.5 h / 5 °C

2.3: 35 - 85 °C

3.1: thionyl chloride / acetic acid butyl ester / 1.5 h / 64 °C

3.2: 20 °C / Cooling with ice

4.1: hydrogenchloride / 1,4-dioxane / 20 °C

4.2: pH 7 - 8

5.1: triethylamine / acetonitrile / 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 1 h / Reflux

6.2: pH 7 - 8

7.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C

7.2: pH 7 - 8

With pyridine; hydrogenchloride; chloro-trimethyl-silane; thionyl chloride; oxalyl dichloride; lithium hydroxide monohydrate; water; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; acetic acid butyl ester; toluene; acetonitrile;

Reference yield:

: 4-[([1,1,-Biphenyl]-2-carbonyl)amino]-2-chlorobenzoic Acid

: 1278520-77-6
(S)-2-(1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / acetic acid butyl ester / 1.5 h / 64 °C

1.2: 20 °C / Cooling with ice

2.1: hydrogenchloride / 1,4-dioxane / 20 °C

2.2: pH 7 - 8

3.1: triethylamine / acetonitrile / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 1 h / Reflux

4.2: pH 7 - 8

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C

5.2: pH 7 - 8

With hydrogenchloride; thionyl chloride; lithium hydroxide monohydrate; water; triethylamine; In tetrahydrofuran; 1,4-dioxane; acetic acid butyl ester; acetonitrile;