4H-Thieno(3,4-b)(1,5)benzodiazepine, 7-chloro-10-(4-methyl-1-piperazinyl)-

Base Information

Chemical Name:4H-Thieno(3,4-b)(1,5)benzodiazepine, 7-chloro-10-(4-methyl-1-piperazinyl)-
CAS No.:59681-54-8
Molecular Formula:C₁₆H₁₇ClN₄S
Molecular Weight:332.857
Hs Code.:
DSSTox Substance ID:DTXSID30208370
ChEMBL ID:CHEMBL355702

Synonyms:BRN 0572402;4H-Thieno(3,4-b)(1,5)benzodiazepine, 7-chloro-10-(4-methyl-1-piperazinyl)-;7-Chloro-10-(4-methyl-1-piperazinyl)-4H-thieno(3,4-b)(1,5)benzodiazepine;59681-54-8;7-chloro-10-(4-methyl-1-piperazinyl)-4H-thieno[3,4-b][1,5]benzodiazepine;C16H17ClN4S;CHEMBL355702;SCHEMBL11533730;DTXSID30208370;KOCCKIVKQCCVIN-UHFFFAOYSA-N;LS-152264;7-chloro-10-(4-methyl-1-piperazinyl)-4H-thieno[3,4-b] [1,5] benzodiazepine

Suppliers and Price of 4H-Thieno(3,4-b)(1,5)benzodiazepine, 7-chloro-10-(4-methyl-1-piperazinyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4H-Thieno(3,4-b)(1,5)benzodiazepine, 7-chloro-10-(4-methyl-1-piperazinyl)-

Chemical Property:

Vapor Pressure:5.09E-10mmHg at 25°C
Boiling Point:497.1°Cat760mmHg
Flash Point:254.4°C
Density:1.44g/cm³
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:332.0862454
Heavy Atom Count:22
Complexity:438

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CSC=C42

Technology Process of 4H-Thieno(3,4-b)(1,5)benzodiazepine, 7-chloro-10-(4-methyl-1-piperazinyl)-

There total 7 articles about 4H-Thieno(3,4-b)(1,5)benzodiazepine, 7-chloro-10-(4-methyl-1-piperazinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59681-53-7
7-chloro-10-methylsulfanyl-4H-benzo[b]thieno[3,4-e][1,4]diazepine

: 1336-21-6
ammonium hydroxide

: 59681-54-8
7-chloro-10-(4'-methyl-1'-piperazinyl)-4H-thieno[3,4-b][1,5]benzodiazepine

Guidance literature:: In 1-methyl-piperazine; chloroform; acetic acid;

Reference yield:

: 59681-67-3
7-chloro-4,9-dihydro-benzo[b]thieno[3,4-e][1,4]diazepine-10-thione

: 59681-54-8
7-chloro-10-(4'-methyl-1'-piperazinyl)-4H-thieno[3,4-b][1,5]benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: KOH / dioxane; methanol

2: AcOH / xylene / Heating

With potassium hydroxide; acetic acid; In 1,4-dioxane; methanol; xylene;
DOI:10.1021/jm00192a020

Reference yield:

: 59681-52-6
7-Chloro-4,9-dihydro-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

: 59681-54-8
7-chloro-10-(4'-methyl-1'-piperazinyl)-4H-thieno[3,4-b][1,5]benzodiazepine

Guidance literature:: Multi-step reaction with 3 steps

1: P₂S₅ / pyridine / Heating

2: KOH / dioxane; methanol

3: AcOH / xylene / Heating

With potassium hydroxide; tetraphosphorus decasulfide; acetic acid; In 1,4-dioxane; pyridine; methanol; xylene;
DOI:10.1021/jm00192a020