3-(6-(2-(4-phenyltetrahydro-2H-pyran-4-yl)ethoxy)pyrazin-2-yl)benzonitrile

Base Information

Chemical Name:3-(6-(2-(4-phenyltetrahydro-2H-pyran-4-yl)ethoxy)pyrazin-2-yl)benzonitrile
CAS No.:1581258-24-3
Molecular Formula:C₂₄H₂₃N₃O₂
Molecular Weight:385.466
Hs Code.:

Synonyms:3-(6-(2-(4-phenyltetrahydro-2H-pyran-4-yl)ethoxy)pyrazin-2-yl)benzonitrile

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Chemical Property of 3-(6-(2-(4-phenyltetrahydro-2H-pyran-4-yl)ethoxy)pyrazin-2-yl)benzonitrile

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Technology Process of 3-(6-(2-(4-phenyltetrahydro-2H-pyran-4-yl)ethoxy)pyrazin-2-yl)benzonitrile

There total 6 articles about 3-(6-(2-(4-phenyltetrahydro-2H-pyran-4-yl)ethoxy)pyrazin-2-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1581258-43-6
2-chloro-6-(2-(4-phenyltetrahydro-2H-pyran-4-yl)ethoxy)pyrazine

: 150255-96-2
(3‐cyanophenyl)boronic acid

: 1581258-24-3
3-(6-(2-(4-phenyltetrahydro-2H-pyran-4-yl)ethoxy)pyrazin-2-yl)benzonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 150 ℃; for 1h; Microwave irradiation;

Reference yield:

: 80813-09-8
cyano(4-phenyltetrahydropyran-4-yl)acetate d'ethyle

: 1581258-24-3
3-(6-(2-(4-phenyltetrahydro-2H-pyran-4-yl)ethoxy)pyrazin-2-yl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide; ethylene glycol / 160 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 0 °C

3.2: 0 - 20 °C

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 150 °C / Microwave irradiation

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; ethylene glycol; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; mineral oil;

Reference yield:

: 33451-54-6
ethyl 2-cyano-2-(dihydro-2H-pyran-4(3H)-ylidene)acetate

: 1581258-24-3
3-(6-(2-(4-phenyltetrahydro-2H-pyran-4-yl)ethoxy)pyrazin-2-yl)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethyl ether / 2 h / Reflux

2.1: potassium hydroxide; ethylene glycol / 160 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 0 °C

4.2: 0 - 20 °C

5.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 150 °C / Microwave irradiation

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; ethylene glycol; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; mineral oil;